Detection of inguinal lymph node involvement in penile squamous cell carcinoma by 18F-fluorodeoxyglucose PET/CT: A prospective single-center study |
| |
Authors: | Boris Schlenker Bernhard Scher Reinhold Tiling Sabine Siegert Edwin Hungerhuber Christian Gratzke Derya Tilki Oliver Reich Peter Schneede Peter Bartenstein Christian G Stief Michael Seitz |
| |
Institution: | 1. Department of Urology, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany;2. Department of Diagnostic and Interventional Radiology and Nuclear Medicine, Hospital Munich-Bogenhausen, Munich, Germany;3. Department of Nuclear Medicine, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany;4. Department of Pathology, Ludwig-Maximilians University, Munich, Germany;5. Department of Urology, Memmingen Hospital, Memmingen, Germany |
| |
Abstract: | BackgroundThe extent of lymph node involvement is the most relevant prognostic factor in patients with penile cancer.ObjectiveTo prospectively analyze the diagnostic accuracy of 18F-FDG-PET/CT-scan in the assessment of inguinal lymph node involvement in patients with invasive penile carcinoma.Patients and methodsThirty-five patients with invasive penile carcinoma were staged prospectively by 18F-FDG-PET/CT-scan, and blindly evaluated by 2 nuclear medicine physicians. In total, lymph node involvement was assessed in 70 inguinal groins. Reference standard was either histology or clinical follow-up with a minimum of 31 months (mean: 48.4 months; range: 31–68 months).Results18-FDG-PET/CT showed a sensitivity of 88.2% and a specificity of 98.1%. Positive predictive value (PPV) was 93.8%, while negative predictive value (NPV) was 96.3%. In two groins, metastasis of 5 and 7 mm were missed by PET/CT scan.Conclusion18F-FDG-PET/CT is a promising staging tool in assessing the inguinal lymph node involvement of patients with penile carcinoma. Integration of PET/CT scanning into preoperative staging algorithms may avoid surgical staging in selected patients. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|