突发性聋与铁代谢障碍疾病关系的临床调查

对１９７９年７月至１９９６年６月的突发性聋发病情况进行前瞻性研究与回顾性分析，探讨突聋与铁代谢障碍疾病的关系，前瞻性研究的对象分为铁代谢障碍疾病组２１８例，血液病组２１５例和正常对照组４８５０例；回顾性分析为１７年间资料完整的４２９例突聋患者史的代谢障碍疾病及其他血液病的发病情况。结果表明，铁代谢障碍疾病组的突聋调整年发病率显著高于血液病组以及正常对照组，４２９例突聋患者的无贫血缺铁，缺铁性人同血

Disturbance of iron metabolism and sudden bearing loss:a prospective and retrospective survey

Two hundred and eighteen patients with disorders of disturbance of ironmetabolism, 215 with hematonosis and 4850 in a normal control group were studied in a prospectivewith sudden hearing loss and were meanwhile investigated in a retropective review in order to e-valuate the relationship between the disorders of sisturvance of iron metabolism and sudden hearingloss. The findings revealed a significantly higher incidence of sudden hearing loss in the cases of dis-turvance of iron metabolism,than. in the patients with hematonosis as well as in the normal controlgroup. Iron deficiency and iron defitiency anemia were found in 60. 84% of 429 patients with sud-den hearing loss. We concluded that the risk of disturbance of iron metabolism in the cochlea willsignificantly increase when systemic disturbance of iron metabolism is present although the onedoes not necessarily indicate the other. lt seems that acute disturbance of iron metabolism incochlea causes sudden hearing loss directly or provides a pathologic basis for the disorder.