超敏C反应蛋白、纤维蛋白原、D-二聚体在冠心病诊断中的临床价值

目的探讨血清超敏C反应蛋白（hypersensitiveC—reactiveprotein，Hs—CRP）、纤维蛋白原（fibrinogen，FIB）、D-二聚体（D—dimer，D—D）与冠心病（coronaryheandisease，CHD）病变程度的相关性。方法回顾性分析156例行冠状动脉造影患者，根据造影结果分为非CHD组56例和CHD组100例．同期测定各组Hs—CRP、D—D和FIB水平，并进行统计学分析。结果CHD组与非CHD组间基线水平比较，除糖尿病史、高血压史差异有统计学意义外，其他指标组间差异均无统计学意义（P均〉0．05）。CHD组血清Hs-CRP、FIB、D—D水平均高于非CHD组，且差异均有统计学意义（P均〈0．01）；CHD各组血清Hs—CRP、FIB、D—D水平随病变严重程度的增高均呈递增趋势，且组间两两比较差异均有统计学意义（P均〈0．05）。多支病变组Hs—CRP、FIB、D—D水平均高于双支病变组（P均〈0．05）和单支病变组（P均〈0．01），双支病变组Hs—CRP、D—D均显著高于单支病变组，差异均有统计学意义（P均〈0．05）。结论血清Hs—CRP、FIB、D—D水平与CHD的严重程度及冠状动脉病变支数相关。

The clinical value of hypersensitive C-reactive protein, fibrinogen and D-dimer in diagnosis of coronary heart disease

Objective To investigate the correlation of hypersensitive C-reactive protein （Hs-CRP）, fibrinogen（FIB） and D-dimer（D-D） with pathological change degree of coronary heart disease（CHD）. Methods 156 cases coronary artery angiography patients were analyzed retrospectivily and divided them into CHD group and non-CHD group according to the results of opacification. The levels of Hs-CRP, FIB and D-D were detected and analyzed. Results There were no statistical significance in the differences of baseline levels except diabetes mellitus and hypertension medical history between CHD group and non-CHD group （Pall〉 0.05）. The levels of Hs-CRP, FIB and D-D in CHD group were all higher than in non-CHD group and the differences all had statistical signifieance（Pall〈0.01）. Among the CHD groups, the levels of Hs-CRP, FIB and D-D showed an increasing trend along with the raisesd up of pathological change degree, and there were all had statistical significance in the differences between each two groups（Pall〈 0.05）. The levels of Hs-CRP, FIB and D-D in multi-vessel lesion group were all higher than that in double-vessel lesion group （Pall〈 0.05） and single-vessel lesion group （Pall〈0.01） and the differences all had statistical significance. The levels of Hs-CRP and D-D in double-vessel group were higher than in single-vessel lesion group and the differences all had statistical significance （Pall〈 0.05）. Conclusion The levels of Hs-CRP, FIB and D-D have correlation with the degree and quantity of diseased vessels in the patients with CHD.