|
|||||
|
|
| 银杏叶提取物对黄曲霉毒素B1所致大鼠肝癌相关蛋白表达影响的研究 | |
| 引用本文： | 杨涛,莫钦国,欧超,苏建家. 银杏叶提取物对黄曲霉毒素B1所致大鼠肝癌相关蛋白表达影响的研究[J]. 中华肿瘤防治杂志, 2011, 18(11) |
| 作者姓名： | 杨涛 莫钦国 欧超 苏建家 |
| 作者单位： | 1. 广西医科大学附属肿瘤医院乳腺外科,广西南宁,530021 2. 广西医科大学附属肿瘤医院肿瘤研究所,广西南宁,530021 |
| 基金项目： | 李嘉诚基金会西部教育计划资助项目(教外港函[2001]33) |
| 摘 要： | 目的:探讨银杏叶提取物(extract761 from Ginkgo giloba,EGb761)对黄曲霉毒素B1(aflatox B1,AFB1)致大鼠肝癌后相关蛋白表达的影响。方法:71只大鼠随机分为AFB1组(28只),AFB1+EGb761组(29只),空白对照组(14只)。第64周观察大鼠肝癌发生率,应用免疫组化法检测硫酸乙酰肝素类蛋白聚糖(MXR7)、环氧化酶(COX-2)以及细胞周期蛋白依赖性蛋白激酶抑制蛋白(p16)的表达情况。结果:AFB1组肝癌发生率明显高于AFB1+EGb761组(76%vs28%),χ2=10.602,P<0.05,对照组无肿瘤发生。AFB1+EGb761组MXR7蛋白含量明显低于AFB1组〔(1.488±1.178)vs(5.133±2.725)〕,F=18.638,P<0.001;AFB1+EGb761组p16蛋白含量明显高于AFB1组〔(2.456±1.014)vs(1.533±0.856)〕,F=24.091,P=0.03,AFB1组COX-2蛋白含量为3.305±0.566;AFB1+EGb761组为2.704±0.431,F=9.352,P=0.783。结论... |
| 关 键 词： | 肝肿瘤 实验性 植物提取物 黄曲霉毒素B1 |
Effects of Ginkgo biloba extract on relative protein expressions during hepatocarcinogenesis aflatoxin B1-induced in Wistar rats |
|
| YANG Tao,MO Qin-guo,OU Chao,SU Jian-jia. Effects of Ginkgo biloba extract on relative protein expressions during hepatocarcinogenesis aflatoxin B1-induced in Wistar rats[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(11) | |
| Authors: | YANG Tao MO Qin-guo OU Chao SU Jian-jia |
| Affiliation: | YANG Tao,MO Qin-guo,OU Chao,SU Jian-jiaGuangxi Cancer Hospital,Guangxi Medical University,Nanning 530021,P.R.China |
| Abstract: | OBJECTIVE: To investigate the effects of Ginkgo biloba extract(extract 761 from Ginkgo giloba,EGb761) on relative protein expressions during hepatocarcinogenesis induced by aflatoxin B1(AFB1) in rats.METHODS: The 71 rats were divided into three groups: Group AFB1(28),Group AFB1+EGb761(29) and Group control(14).The animals were sacrificed at the end of the experiment.The incidence of liver cancers in each group was stated.The expressions of heparan sulfate proteoglycan(MXR7),Cycloxygenase-2(COX-2) and Cyclin... |
| Keywords: | liver neoplasms experimental plant extracts aflatoxin B1 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |