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| MTDH与肿瘤关系的研究进展 | |
| 引用本文： | 王启明,谢晓冬. MTDH与肿瘤关系的研究进展[J]. 中华肿瘤防治杂志, 2011, 18(14): 1138-1140 |
| 作者姓名： | 王启明 谢晓冬 |
| 作者单位： | 沈阳军区总医院肿瘤科,辽宁沈阳,110016 |
| 基金项目： | 辽宁省自然科学基金(20082070) |
| 摘 要： | 目的:总结异黏蛋白(MTDH)的功能及其作用的分子机制,探讨MTDH与肿瘤的关系。方法:应用Medline、PubMed及CNKI期刊全文数据库检索系统,以"MT-DHt、umor"等为检索词,检索2005-2010年相关文献29条。纳入标准:1)MTDH的功能;2)MTDH作用机制;3)MTDH与肿瘤的关系。根据纳入标准,符合分析的文献18篇。结果:MTDH基因在肿瘤进展中起着重要的作用,包括促进肿瘤细胞增殖、侵袭和转移、避免凋亡及促使肿瘤细胞对化疗药物产生耐药。MTDH通过激活NF-κB、PI3K/AKT、MAPK与wnt/-βcatenin信号通路来促进肿瘤的发生发展。结论:深入研究MTDH在恶性肿瘤中的表达及功能有助于理解肿瘤发生发展的分子机制。MTDH基因有望成为治疗肿瘤的有效靶点。 |
| 关 键 词： | 异黏蛋白 信号通路 肿瘤 综述文献 |
Progress in research of MTDH and its relation with tumors |
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| WANG Qi-ming,XIE Xiao-dong. Progress in research of MTDH and its relation with tumors[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(14): 1138-1140 | |
| Authors: | WANG Qi-ming XIE Xiao-dong |
| Affiliation: | WANG Qi-ming,XIE Xiao-dong Department of Oncology,General Hospital of Shenyang Military Region,Shenyang 110016,P.R.China |
| Abstract: | OBJECTIVE: To summarize the function of MTDH and molecular mechanism of MTDH,and explore the relationship between MTDH and tumor.METHODS: A total of 29 English papers were searched with MTDH and tumor as in Medline and Pubmed databases from 2005 to 2010.Eighteen papers were selected according to the standards as follows: 1)The function of MTDH;2)The molecular mechanism of MTDH action;3)The relationship between the MTDH and tumors.RESULTS:MTDH plays a functional role in several crucial aspects of tumor progr... |
| Keywords: | metadherin signal pathway neoplasms review literature |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |