| 海洋真菌Cladosporium cladosporioides化学成分研究 |
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| 引用本文： | 邹建华,戴均贵.海洋真菌Cladosporium cladosporioides化学成分研究[J].中国药学杂志,2009,44(6):418-421. |
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| 作者姓名： | 邹建华 戴均贵 |
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| 作者单位： | 中国医学科学院-北京协和医学院药物研究所,中草药物质基础与资源利用教育部重点实验室,卫生部天然药物生物合成重点实验室 北京 100050 |
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| 基金项目： | 国家自然科学基金资助项目(20602042) |
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| 摘 要： | 目的对来源于红树林的海洋真菌Cladosporium cladosporioides的发酵产物进行化学成分研究。方法采用溶剂提取、硅胶柱色谱及半制备HPLC等分离方法对真菌菌丝体进行分离纯化,通过波谱学方法进行结构鉴定。结果分离得到10个化合物,分别为二十四烷酸(1)、麦角甾-5,7,22-三烯-3β-醇(2)、24-亚甲基羊毛脂甾-8-烯-3β-醇(3)、1-(硬脂酸)-2-(亚油酸)-3-油酸甘油酯(4)、1,2,3-三亚油酸甘油酯(5)、1,3-二油酸甘油酯(6)、肉桂酸(7)、苯丙酸(8)、β-谷甾醇(9)、丁二酸单乙酯(10)。结论化合物1～10均为首次从该菌种分离得到。
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| 关 键 词： | Cladosporiumcladosporioides 海洋真菌 次生代谢产物 |
| 收稿时间： | 2008-04-03; |
Study on Chemical Constituents in Marine Fungus of Cladosporium cladosporioides |
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| ZOU Jian-hua,DAI Jun-gui.Study on Chemical Constituents in Marine Fungus of Cladosporium cladosporioides[J].Chinese Pharmaceutical Journal,2009,44(6):418-421. |
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| Authors: | ZOU Jian-hua DAI Jun-gui |
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| Institution: | Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Key Laboratory of Biosynthesis of Natural Products,Ministry of Public Health,Beijing 100050,China |
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| Abstract: | OBJECTIVE To investigate the chemical constituents of marine fungus Cladosporium cladosporioides from mangrove. METHODS The components were isolated by means of solvent extraction,silica gel column chromatography and semi-preparative HPLC. The structures were elucidated by spectral analysis. RESULTS Ten compounds were isolated and identified as tetracosanoic acid (1) ,ergosta-5 ,7,22-trien-3β-ol (2) ,eburicol (3) ,1-(octadecanoyl)-2-(cis,cis)-9,12-octadecadienoyl-3-(cis)-9-octadecenoyl-glycerol (4),1,2,3-trilinolein (5),glycerol 1,3-bisoleate (6),cinnamic acid (7),3-phenyl-propionic acid (8),β-sitosterol (9),succinic acid monoethyl ester (10). CONCLUSION These compounds were obtained from the fungus for the first time. |
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| Keywords: | Cladosporium cladosporioides" target="_blank">Cladosporium cladosporioides')" href="#">Cladosporium cladosporioides marine fungus secondary metabolites |
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