| 藻酸双酯钠及其分级产物免疫调节作用比较研究 |
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| 引用本文： | 林长征,管华诗,于广利,李海花,谷彩霞.藻酸双酯钠及其分级产物免疫调节作用比较研究[J].中国海洋药物,2007,26(5):13-16. |
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| 作者姓名： | 林长征 管华诗 于广利 李海花 谷彩霞 |
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| 作者单位： | 海洋药物教育部重点实验室,中国海洋大学医药学院,山东,青岛,266003 |
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| 摘 要： | 目的探讨海洋药物藻酸双酯钠(PSS)的免疫调节作用及其构效关系。方法采用体外免疫细胞培养法检测PSS及其分级产物的免疫调节作用,根据分级产物结构差异,探讨PSS分级产物的免疫活性构效关系。结果PSS能够促进脾脏淋巴细胞的增殖,提高巨噬细胞吞噬功能,同时能抑制刀豆蛋白A(ConA)及脂多糖(LPS)促进的免疫细胞的增殖作用。结论PSS具有显著的免疫调节作用,不同的糖链长度对免疫细胞作用不同。
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| 关 键 词： | 藻酸双酯钠 多糖 相对分子质量 免疫调节 |
| 文章编号： | 1002-3461（2007）05-0013-04 |
| 修稿时间： | 2007-01-23 |
Comparative study on immunoregulation of sulfated propylene glycol alginate and its fractions |
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| LIN Chang-zheng,GUAN Hua-shi,YU Guang-li,LI Hai-hu,GU Cai-xia.Comparative study on immunoregulation of sulfated propylene glycol alginate and its fractions[J].Chinese Journal of Marine Drugs,2007,26(5):13-16. |
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| Authors: | LIN Chang-zheng GUAN Hua-shi YU Guang-li LI Hai-hu GU Cai-xia |
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| Institution: | Institute of Marine Drug and Food, Ocean University of China, Qingdao 266003, China |
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| Abstract: | Objective To investigate the influence of sulfated propylene glycol alginate(PSS) and its fractions on the immunoregulation.Methods The immunoregulation activity of PSS and its fractions were investigated by using immunocyte cultivation technique in vitro.The structure activity relationship was analysed on the basis of the structure studies of PSS' fractions.Results The experimental results showed that PSS could improve spleen cell proliferation,enhance macrophage phagocytic function and inhibit T-cell and B-cell proliferation.Conclusion PSS possessed significant immunoregulation effect,whilst the immunocompetence comparison of PSS' fractions proved that the different immunocytes had different requirements for saccharides length. |
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| Keywords: | sulfated propylene glycol alginate polysaccharides molecular weight immunoregulation |
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