缺血性中风中医辨证分型与ICAM-1和CD62P表达水平的相关性 |
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引用本文: | 祝美珍,李志刚.缺血性中风中医辨证分型与ICAM-1和CD62P表达水平的相关性[J].中国中西医结合杂志,2005,25(3):225-227. |
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作者姓名: | 祝美珍 李志刚 |
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作者单位: | 广西中医学院基础医学院中医诊断学教研室,南宁,530001 |
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摘 要: | 目的观察缺血性中风中医证型与血中性粒细胞表面细胞间黏附分子(ICAM-1)和血小板膜上P选择素(CD62P)变化的关系,探讨缺血性中风的发病机理。方法将72例缺血性中风患者按中医辨证分为3个证型组:即痰瘀阻络型组、痰热腑实型组和气虚血瘀型组,每组24例,另设一健康人对照组(24名)、用流式细胞仪测定各组患者的ICAM-1、CD62P的表达水平。结果缺血性中风患者ICAM-1、CD62P水平均显著高于健康人对照组(P<0.01),其中痰瘀阻络型组ICAM-1的表达水平显著高于气虚血瘀型组和痰热腑实型组(P<0.01);痰瘀阻络型组和气虚血瘀型组CD62P的表达水平显著高于痰热腑实型组(P<0.01)。结论缺血性中风不同证型的ICAM-1、CD62P表达水平存在一定的差异性,ICAM-1反映了体内痰阻或痰瘀互结的病理状态,而CD62P则反映了体内血瘀状态。提示痰瘀阻络可能是缺血性中风的病机关键.
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关 键 词: | 缺血性中风 辨证分型 ICAM-1 CD62P 表达 相关性 |
修稿时间: | 2004年8月19日 |
Study on Correlationship of TCM Syndrome Type and Expression of ICAM-1, CD62P in Patients with Ischemic Stroke |
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Authors: | ZHU Mei-zhen and LI Zhi-gang |
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Abstract: | study the correlationship between TCM Syndrome type with changes of neutrophil surface intercellular adhesion molecule-1 (ICAM-1) and platelet membrane P selectin (CD62P) in patients with ischemic stroke for exploring the pathogenesis of the disease. MethodsSeventy-two patients with ischemic stroke were dividcd into 3 typing groups according to TCM syndrome-differentiation, the Meridian-phlegm stagnancy group (MPS), the visceral phlegm-heat accumulation group (VPHA) and the qi-deficiency with blood stasis group (QDBS), 24 in each group. Besides, a control group consisted of 24 healthy subjects was set up. Blood levels of ICAM-1 and CDP62 expression were monitored by flow cytometry. ResultsBlood levels of ICAM-1 and CD62P expression in ischemic stroke patients were significantly higher than those in healthy subjects (P<0.01). Among the three type groups, ICAM-1 expression was significantly higher in MPS than that in the VPHA and the QDBS group (P<0.01), and CD62P expression in the MPS and the QDBS group was significantly higher than that in the VPHA (P<0.01). Conclusion Blood levels of ICAM-1 and CD62P expression in different typing of patients with ischemic stroke are different. ICAM-1 expression reflects the pathological state of phlegm retention or phlegm-stasis mutual bindings, CD62P expression reflected the blood stasis state in organism, these evidences suggest that MPS may be the key pathogenic factor of ischemic stroke. |
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Keywords: | ischemic stroke TCM Syndrome typing neutrophil surface intercellular adhesion molecule-1 platelet membrane P selectin |
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