ACS患者中测定血清炎性细胞因子水平变化的临床应用分析

目的:为了探讨急性冠状动脉综合征(ACS)患者测定血清炎性细胞因子水平变化的临床应用分析.方法:采用放射免疫分析和超敏酶免疫分析112例ACS患者,其中46例急性心肌梗死(AMI)患者,66例为不稳定型心绞痛(UAP)患者和32例稳定型心绞痛(SAP)患者血清IL-1β、IL-6、IL-8、TNF-α和hs-CRP水平...

Analysis of Clinical Application on Determining Serum Inflammatory Cytokines Levels in Patients with Acute Coronary Syndrome

Objective To evaluate analysis of clinical application on determining serum inflammatory cytokines levels in patients with acute coronary syndrome(ACS).Methods The levels of interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8),high-sensitive C-reaction protein(hs-CRP)(with high-sensitive enzyme immunoassay) and tumor necrosis factor-α(TNF-α)(with radioimmunoassay) in serum were determined in 112 patients with ACS,32 patients with stable angina pectoris(SAP) and 42 normal controls as well as did compared analysis.Results The serum IL-1β,IL-6,IL-8,TNF-α and hs-CRP levels in 112 patients with ACS were obviously higher than those in 42 controls(P all<0.01),but in 32 patients with stable angina pectoris(SAP) were no significantly than those in 42 controls(P all>0.05),serum hs-CRP level was increased only(P<0.05).The serum IL-1β,IL-6,IL-8,TNF-α and hs-CRP levels in 46 patients with acute myocardial infraction(AMI) were prominently higher than those in 66 patients with unstable angina pectoris(UAP) and in 32 patients with SAP.The serum IL-1β,IL-6,IL-8,TNF-α and hs-CRP levels with advanced degree SAP,UAP and AMI were increased.Conclusion In the severity of the patients with SAP,UAP,AMI,the determination of serum inflammatory cytokines level were a good and important index,so that it was referential for heart coronary events happened.