Telomerase activity in human gastric and colorectal cancer and surrounding tissues |
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| Authors: | Wen Chen Qiao Zhang De-sen Wan Ling-yun Cun Cheng-qiu Wu Zhi-zhong Pan |
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| Institution: | (1) Department of Health Toxicology, School of Public Health, Sun Yat-Sen University of Medical Sciences, No. 74, Zhong Shan 2 Road, 510089 Guangzhou, China;(2) Department of Surgery, Cancer Center, Sun Yat-Sen University of Medical Sciences, 510089 Guangzhou, China |
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| Abstract: | Objective: To study the telomerase activities inhuman gastric and colorectal tumors. Methods: Thetelomerase activity was assayed by the telomeric repeatamplification protocol (TRAP) technique. Forty humantumor samples including 9 colonic, 20 rectal and 11gastric carcinomas and their surrounding tissues wereused for the detection. Results: Thirty-six out of 40human tumor samples exhibited telomerase activityregardless of the stages or the differentiation of thetumors. However, only 1 out of 39 tumor surroundingtissues showed telomerase activity. Conclusion: Telomerase may be a good diagnosis biomarker for tumordetection. |
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| Keywords: | Stomach neoplasms Colonic neoplasms Rectal neoplasms Telomerase armor biomarkers |
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