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槐定的大鼠胚胎毒性和致畸性研究
引用本文:朱永平 祝慧娟. 槐定的大鼠胚胎毒性和致畸性研究[J]. 癌变.畸变.突变, 1995, 7(3): 152-155
作者姓名:朱永平 祝慧娟
作者单位:浙江杭州医科大学毒理研究室
摘    要:
Wistar大鼠于孕期d6-15ip槐定27、9、3mg/kg,结果高剂量组孕鼠平均增重减少,与阴性对照组相比,死胎率明显上升,胎鼠生长发育迟缓;中、低剂量组未见明显影响。各剂量组未见畸形胎鼠。本研究结果表明,槐定27mg/kg(约为临床治疗剂量的27倍)对Wistar孕鼠具有胚胎毒性,但无致畸作用。

关 键 词:中药 槐定 胚胎毒性 致畸作用 毒性

EMBRYOTOXlCITY AND TERATOGENICITY STUDY OFSOPHORIDINE IN WISTAR RATS
Abstract:
The embryotoxicity and teratogenicity of sophoridine were investigated in wistarrats. Sophoridine was administered at 27,9,3mg/kg ip on day 6-15 of the gestation. Ascompared to the solvent control,high dosage of sophoridine(27mg/kg,about 27 times ofclinical dosage)was toxic to pregnant rats and induced embryotoxicity,as measured by per-centage of dead fetuses and delayed skeletogency,No malformation of survial fetuses was ob- served in every group.These studies indicated that sophoridine is embryotoxic,but not ter- atogenic in Wistar rats.
Keywords:Sophoridine  Embryotoxicity  Yeratogenicity
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