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| OLETF大鼠脂肪组织chemerin及其受体1的基因表达 | |
| 引用本文： | 李冰,杨菊红,王楠,梁东春,江昌新,冯凭.OLETF大鼠脂肪组织chemerin及其受体1的基因表达[J].中华内分泌代谢杂志,2010,26(5). |
| 作者姓名： | 李冰 杨菊红 王楠 梁东春 江昌新 冯凭 |
| 作者单位： | 1. 300052天津医科大学总医院代谢病科 2. 天津内分泌研究所 3. 天津医科大学基础医学院病理学教研室 |
| 摘 要： | 用实时定量PCR检测OLETF大鼠脂肪组织中chemerin及其受体1 mRNA的表达,结果两者表达水平较对照组明显升高(P<0.05或P<0.01),且网膜脂肪组织高于皮下脂肪组织(P<0.05或P<0.01),说明脂肪因子chemerin及其受体1基因表达的变化可能是肥胖、胰岛素抵抗和2型糖尿病发病的机制之一. |
| 关 键 词： | 实时PCR 基因表达 |
mRNA expressions of chemerin and its receptor 1 in adipose tissue of OLETF rats |
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| LI Bing,YANG Ju-hong,WANG Nan,LIANG Dong-chun,JIANG Chang-xin,FENG Ping.mRNA expressions of chemerin and its receptor 1 in adipose tissue of OLETF rats[J].Chinese Journal of Endocrinology and Metabolism,2010,26(5). | |
| Authors: | LI Bing YANG Ju-hong WANG Nan LIANG Dong-chun JIANG Chang-xin FENG Ping |
| Abstract: | The mRNA expressions of chemerin and its receptor CMKLR1 in adipose tissue of OLETF rats and LETO rats were detected by real-time PCR. The results showed that the two genes mRNA expressions in subcutaneous and visceral adipose tissue in OLETF group were significantly higher than those in LETO group (P< 0.05 or P<0.01) and expressions of them in visceral adipose tissue were higher than those in subcutaneous adipose tissue(P<0. 05 or P<0. 01), suggesting that chemerin and CMKLR1 may be involved in the pathogenesis of obesity, insulin resistance, and type 2 diabetes mellitus. |
| Keywords: | OLETF Chemefin CMKLR1 |
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