| ~(32)P玻璃微球间质治疗联合加热对肿瘤微血管作用的实验研究 |
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| 引用本文： | 汪永跃,王大章,郑光勇,毛祖彝.~(32)P玻璃微球间质治疗联合加热对肿瘤微血管作用的实验研究[J].口腔医学研究,1998(2). |
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| 作者姓名： | 汪永跃 王大章 郑光勇 毛祖彝 |
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| 作者单位： | 华西医科大学口腔医学院!成都市，610041，北京市309医院口腔科，100091，华西医科大学口腔医学院!成都市，610041，华西医科大学口腔医学院!成都市，610041，华西医科大学口腔医学院!成都市，610041 |
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| 基金项目： | 国家自然科学基金!73870834 |
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| 摘 要： | 目的为了解间质治疗对肿瘤微血管的作用以及加热作用对其的影响。方法采用光镜和电镜观察了移植性小鼠S180实体瘤在32P－GMS间质治疗后及其联合加热治疗后的血管铸型及墨汁灌注切片。结果加热组、放疗组均可引起肿瘤微血管的扩张，新生血管抑制，毛细血管数量减少及瘤周血管密度降低，联合治疗组作用更明显。结论加热对肿瘤微血管的损伤与射线对其损伤在形态学方面相似；内照射的损伤作用与外照射的作用相似。放射及加热联合对肿瘤微血管的损伤可能增强。
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| 关 键 词： | ~(32)P玻璃微球 间质治疗 加热 血管铸型 |
A study of effect of internal irradiotherapy with 32 P glass micrespheres in combination with hyperthermia on mouse tumor vasculature |
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| Wang Yongyue, Wang Dazhang, Zheng Guangyong,et al..A study of effect of internal irradiotherapy with 32 P glass micrespheres in combination with hyperthermia on mouse tumor vasculature[J].Journal of Oral Science Research,1998(2). |
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| Authors: | Wang Yongyue Wang Dazhang Zheng Guangyong |
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| Abstract: | Objective To investigate teh effect of internal irradiotherapy with 32 P glass microspheres in combinationwith hyperthermia on mouse tumor vasculature. Methods The present study compa red the vascular changes of mousetumor S180 following internal irradiotherapy with 32 P glass microspheres and hyperthermia. Results The expanded microvessels, the restrained new vessels, the decreased microvessels, and the descended peritumoral vascular density in hyperthermia group, irradiotherapy group and united group were observed. Conclusion The injury of microvasculature by hyperthermia is similar to the change by radioaction, and the effect of internal irradiotherapy on tumor microvasculature maybe enhanced by hyperthermia. |
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| Keywords: | ~(32)P glass microspheres internal irradiotherapy hyperthermia cast |
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