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| N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布 | |
| 引用本文： | 毕文杰,肖莉,郑翔. N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布[J]. 解剖学报, 2013, 44(4): 456-462. DOI: 10.3969/j.issn.0529-1356.2013.04.003 |
| 作者姓名： | 毕文杰 肖莉 郑翔 |
| 作者单位： | 1. 成都医学院解剖学教研室，成都 610083; 2. 四川大学华西基础医学与法医学院基础医学专业实验室，成都 610041 |
| 基金项目： | 成都医学院校基金课题资助项目 |
| 摘 要： | 目的 获取大鼠脑部的N-甲基-D-天门冬氨酸受体2A（NMDAR 2A）表达强度分布的数据。方法 通过免疫组织化学染色和图像分析，对成年雄性SD大鼠（n=6）不同脑区的NMDAR 2A表达进行检测。结果 得到大鼠全脑各主要结构NMDAR 2A 表达强度的数据，并绘制图谱。结论 获得的NMDAR 2A表达图谱可为原位检测鼠 脑NMDAR 2A的实验提供参考。 |
| 关 键 词： | 脑 N-甲基-D-天门冬氨酸受体2A 免疫组织化学 大鼠 |
| 收稿时间： | 2012-05-07 |
N-methyl-D-aspartate receptor 2A expression intensity in brain regions of adult male SD rats |
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| BI Wen-jie , XIAO Li , ZHENG Xiang. N-methyl-D-aspartate receptor 2A expression intensity in brain regions of adult male SD rats[J]. Acta Anatomica Sinica, 2013, 44(4): 456-462. DOI: 10.3969/j.issn.0529-1356.2013.04.003 | |
| Authors: | BI Wen-jie XIAO Li ZHENG Xiang |
| Affiliation: | 1. Department of Anatomy, Chengdu Medical College, Chengdu 610083,China; 2. Laboratory of Preclinical Medicine,West China School of Preclinical Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, China |
| Abstract: | Objective N-methyl-D-aspartate receptor (NMDAR) is an important excitatory receptor within the central nervous system. Its 2A subunit is a critical functional subunit. There is no comprehensive data about NMDAR 2A expression intensity in rat brain. Methods In this experiment, we detected NMDAR 2A expression in the brain of adult male SD rat (n=6) with immunohistochemistry staining and image analysis. Results We drew the expression intensity atlas of rat brain based on the immunohistochemical staining intensity. Conclusion These data can provide a reference for in situ detection of NMDAR 2A in related experiments. |
| Keywords: | Brain N-methyl-D-aspartate receptor2A Immunohistochemistry Rat |
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