特利加压素联合大剂量白蛋白治疗肝硬化肝肾综合征的疗效观察

目的观察特利加压素及其联合大剂量白蛋白治疗肝肾综合征的疗效。方法53例患者分为三组，在综合治疗的基础上，A组使用多巴胺，B组使用特利加压素，C组使用特利加压素联合大剂量白蛋白。治疗期间观察患者临床症状、尿量、血肌酐、腹水消长情况。终止治疗事件及治疗后的转归。结果B、C组尿量、肌酐清除率显著增加。血肌酐降低，且C组变化比B组明显，A组仅轻度改善，三组间比较有显著差异。结论特利加压素对肝肾综合征的治疗有确切的疗效．大剂量白蛋白扩容可提高特利加压素对肾功能的作用。

Observation of terlipressin with albumin infusion in management of patients with hepatorenal syndrome

Objective To observe the effect of terlipressin with large dose of albumin in management of patients with hepatorenal syndrome. Methods 53 patients were divided into three groups and in group A, low-dose of dopamine were used, in group B terlipressin were used and terlipressin with large dose of albumin was used in group C. The clinical symptoms, the total urine output and serum creatinine level were observed during treatment. Result In group B and group C, the total urine output and serum creatinine clearing test were increased significantly; the serum creatinine level were decreased remarkably. The patients in group C achieved better effect than that in group 13. Conclusion Terlipressin is effective on hepatorenal syndrome. Terlipressin with large dose of albumin can get enhanced results.