| 经口与经直肠硫酸吗啡控释片治疗癌痛的对比观察 |
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| 引用本文： | 张卓奇,李中,张军华,张刚,陈保平. 经口与经直肠硫酸吗啡控释片治疗癌痛的对比观察[J]. 实用疼痛学杂志, 2008, 4(5): 347-349 |
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| 作者姓名： | 张卓奇 李中 张军华 张刚 陈保平 |
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| 作者单位： | 河北省保定市河北大学附属医院肿瘤科,071000 |
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| 摘 要： | 目的比较硫酸吗啡控释片口服和直肠给药对中、重度癌性疼痛的疗效和不良反应。方法中、重度癌痛患者86例随机分为A组（46例）和B组（40例）,分别口服或直肠应用硫酸吗啡控释片治疗癌性疼痛。结果A组和B组的疼痛缓解率（84.8%,39/46例对82.5%,33/40例）和不良反应发生率（34.8%,16/46例对45.0%,18/40例）的差异无统计学意义。结论经直肠应用硫酸吗啡控释片控制癌性疼痛与经口给药一样安全、有效。
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| 关 键 词： | 硫酸吗啡控释片 癌 疼痛 |
Comparison of effectiveness and side effects of oral and rectal morphine sulfate controlled-release tablets in pain treatment for advanced cancer pain |
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| Affiliation: | ZHANG Zhuo -qi , LI Zhong , ZHANG Jun-hua , et al.( Oncology Department of the Affiliated Hospital of Hebei University, Baoding 071000, China.) |
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| Abstract: | Objective To compare the effectiveness and side effects of morphine sulfate controlled-release tablets in pain treatment for advanced cancer pain per oral and rectum. Methods Eighty six patients with midrange and severe pain induced by advanced carcinoma were divided into group A （46 cases） and group B （40 cases） randomly, group A was treated with morphine sulfate controlled-release tablets orally. Group B was treated per rectum. Results The difference of effectiveness （84.8%, 36/46 cases vs 82.5%, 33/40 cases） and side effect ratio （34. 8%, 16/46 cases vs 45.0%, 18/40 cases） between two groups was not significant. Conclusion It is safe and effective to apply the morphine sulfate controlled-release tablets to treat the cancer pain per rectum, just like Orally. |
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| Keywords: | Morphine Sulfate Controlled-Release Tablets Carcinoma Pain |
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