2型糖尿病患者抗糖尿病药物治疗与血糖控制状况分析

目的了解2型糖尿病患者降糖药物用药现状,分析选择药物对血糖控制的影响,为合理治疗提供依据。方法调查入院时2型糖尿病患者群降糖药物使用状况、血糖控制水平及低血糖情况,根据用药情况分为胰岛素组和口服药组,比较胰岛素组和口服药组的血糖控制水平及低血糖的发生率。结果入选288例2型糖尿病患者,平均HbA1c 8.0%,血糖达标率36.8%。胰岛素组和口服药组的空腹血糖、餐后2 h血糖、体质量指数、HbA1c的控制水平相似。胰岛素组的病程明显长于口服药组([11.5±7.0)年vs(8.1±6.0)年],P=0.000)。口服药组的达标率明显优于胰岛素组(43.4%vs 27.0%,P=0.005)。胰岛素组的低血糖发生率高于口服药组(5.2%vs 1.2%,P=0.041)。结论 2型糖尿病患者群血糖达标率低,启动胰岛素治疗迟、超重和低血糖是影响血糖达标重要原因。

Analysis on hypoglycemic agents and glycemic control in type 2 diabetes mellitus

Objective To find out the current state of medical treatment of type 2 diabetes mellitus,and to analyze the effect of different types of medicine on glycemic control,in order to contribute to a proper therapy.Methods The utility of hypoglycemic agents,levels of blood glucose and hypoglycemia among patients admitted by hospital were investigated by categorizing them into two groups,the insulin group and the oral hypoglycemic agents(OHA) group.Results Completed study was obtained in 288 patients,among whom the average HbA1C was 8.0% and total success rate of glycemic control was 36.8%.There were similarities in ages,levels of fasting plasma glucose(FPG),2 h plasma glucose after meal(2 hPG),body mass index(BMI) and HbA1c.We could see a longer disease course in insulin group(11.5±7.0 vs.8.1±6.0,P=0.000) and a higher success rate of glycemic control in OHA group(43.4% vs.27.0%,P=0.005),followed by a higher proportion of hypoglycemia in insulin group(5.2% vs.1.2%,P=0.041).Conclusion There is a low success rate of glycemic control in type 2 diabetes population,while starting insulin treatment late,overweight and hypoglycemia are important causes affecting success rate of glycemic control.