乳腺癌骨转移的高危因素分析

目的探讨可能影响因素与乳腺癌骨转移发生的相关性。方法回顾分析2007年1月至2010年9月间172例乳腺癌患者中76例骨转移患者,对年龄、病理类型、腋窝淋巴结有无转移及数目、HER-2状况、原发肿块大小、激素受体状况、Ki-67等因素进行分析,了解其与骨转移发生是否有相关性。结果乳腺癌发生骨转移与腋窝淋巴结有无转移、HER-2状况、激素受体情况、Ki-67有相关性,与年龄无相关性。结论乳腺癌患者腋窝淋巴结转移4个及以上、HER-2高表达、激素受体阳性、Ki-67高表达患者,骨转移发生率相对较高,应加强术后定期随访,对同时具备多项骨转移高危因素的乳腺癌患者,术后化疗后可预防性应用骨保护药物。

Analysis of high risk factors of bone metastases in breast cancer

Objective To investigate the correlation between the following related factors and bone metastases in breast cancer.Methods A total of 76 patients with bone metastases in breast cancer among 172 breast cancer patients during 2007 to 2010 were retrospectively analysed.Factors such as age,pathological types,axillary lymph node metastases and their number,HER-2,estrogen and progesteron receptor,tumor size,Ki-67 were analysed to clarify whether there was any correlation with bone metastases in breast cancer.Results Bone metastases in breast cancer were associated with axillary lymph node metastases and their number,HER-2,estrogen and progesteron receptor,Ki-67,but there was no correlation with age.Conclusion Breast cancers patients with more than 4 axillary lymph node metastases,positive HER-2,positive estrogen and progesteron receptor and high expression of Ki-67 are more likely to undergo bone metastases.These patients should strengthen the regular follow-up after operation.Patients who have several risk factors should use bone protection drugs after operation and adjuvant chemotherapy as preventive measures.