不同抗酸药防治非甾体类抗炎药胃粘膜损伤的疗效观察

目的探讨不同抗酸措施在防治服用非甾体类抗炎药患者的胃粘膜损伤中的作用。方法选择2004年1月-2006年11月我院门诊风湿性疾病患者120例,随机分为3组,均维持原来治疗方案,继续服用NSAIDs 3个月。同时,为防治胃粘膜损伤,A组应用奥美拉唑20 mg,口服,1次/d。B组应用雷尼替丁150 mg,2次/d,铝碳酸镁嚼片2 g,2次/d口服。C组应用雷尼替丁150 mg,2次/d。3组观察时间为3个月。观察胃粘膜损伤以及上消化道症状的发生率。结果A、B组较C组胃粘膜损伤的发生率以及上消化道症状发生率明显降低(P<0.05)。结论对服用非甾体类抗炎药患者,服用奥美拉唑或雷尼替丁+铝碳酸镁较服用雷尼替丁有更好的防治胃粘膜损伤的作用。

Therapeutic effect of different anti-acid drugs on the gastric mucosa damage induced by nonsteroidal anti-inflammatory drugs

Objective To explore the effect of different anti-acid drugs on the gastric mucosa damage induced by nonsteroidal anti-inflammatory drugs.Methods One hundred and twenty out-patients were divided into three groups randomly.They all maintained the original treatments.Group A were administered Omeprazole 20 mg,PO,once a day;Group B were administered Ranitidine 150 mg,PO,two times a day,Hydrotalcite,2 g,PO,two times a day;Group C were only administered Ranitidine 150 mg,PO,two times a day.The rate of gastric mucosa damage and uncomfortable upper gastrointestinal response of 3 groups were observed.Results Compared with Group C,the rate of gastric mucosa damage and uncomfortable upper gastrointestinal response in Group A and Group B were decreased significantly(P<0.05).Conclusion Omeprazole and Ranitidine plus Hydrotalcite have more protective effect on gastric mucosa damage induced by nonsteroidal anti-inflammatory drugs.