抗精神病药物诱导性心血管疾病方面的研究进展

精神分裂症是一种复杂的多维度障碍,在药物治疗过程中产生的药物诱导性心血管疾病是导致死亡的最主要原因之一,抗精神病药物对诱导心血管疾病发病的不同风险因素具有促进作用,因此患者发生代谢综合征和心血管疾病的风险很高,另外患者很少能够得到最优化的心血管疾病治疗。某些抗精神病药物尤其是氯氮平和奥氮平,经常导致体重增加,血脂异常和糖尿病等。所以精神分裂症、抗精神病药物和心血管疾病的联系需要做进一步的研究,需要更好的治疗方案,降低患者的心血管疾病的发生率和死亡率。

The research development about cardiovascular aspects of antipsychotics

Schizophrenia is associated with increased mortality and reduced life expectancy,with cardiovascular disease being the most frequent cause of death.Antipsychotics have detrimental effects on different risk factors for cardiovascular disease.This review will focus on the relationship between antipsychotic treatment and cardiovascular disease.Some antipsychotic such as Clozapine and Olanzapine which could lead to gain weight,dyslipidemia,diabetes and so on.More research is needed to better understand the rela...