QTc间期离散度与2型糖尿病及其合并冠心病的关系

目的：研究2型糖尿病及其合并冠心病QTc间期离散度（QTcd）的变化。方法：测量计算86例2型糖尿病患者的QTcd,并分为糖尿病1组（未合并冠心病）44例,糖尿病2组（合并冠心病）42例,并测量40例冠心病患者（冠心病组）的QTcd及40例对照组的QTcd,进行组间对比。结果：糖尿病1组的QTcd较对照组显著增大（P〈0.01）,糖尿病2组的QTcd较糖尿病1组增大,差异有统计学意义（P〈0.05）,糖尿病1组及冠心病组的QTcd均较对照组增大（P〈0.01）,虽然糖尿病1组的QTcd较冠心病组略小,但该两组间差异无统计学意义（P〉0.05）,糖尿病2组与冠心病组比较,QTcd显著增大,差异有统计学意义（P〈0.05）。结论：测量QTcd对预测2型糖尿病心血管事件有重要意义。

The relationship between QTc interval dispersion and type 2 diabetes mellitus and its with coronary heart disease

Objectives： To study QTc dispersion（QTcd） in patients with type 2 diabetes mellitus and in those combined with both type 2 diabetes mellitus and coronary heart disease（CHD）.Methods： 86 patients with type 2 diabetes mellitus were divided into 2 groups,diabetes group 1 of 44 patients（without CHD）,diabetes group 2 of 42 patients（with CHD）,at the same time,measured QTcd in 40 patients only with coronary heart disease（CHD） and that in control group of 40 cases,compared them with each other.Results： QTcd in diabetes group 1 was larger than that in control group（P0.01）,QTcd in diabetes group 2 was larger than that in diabetes group 1,there was significant difference between them（P0.05）.QTcd in diabetes group 1 and group CHD were all larger than that in control group（P0.01）,though QTcd in diabetes group 1 was little shorter than that in group CHD,but there was no significant difference between them（P0.05）.QTcd in diabetes group 2 was larger than that in group CHD,there was significant difference between them（P0.05）.Conclusion： It is very useful of predicting the incident of cardiovascular disease in type 2 diabetes mellitus to measure QTcd.