辐射诱发胸腺淋巴瘤中包含易位的染色体畸变

为了研究包含易位的染色体畸变在辐射诱发淋巴瘤过程中的作用，作者分析了供体型Ｔ淋巴瘤细胞的染色体Ｇ带核型。结果观察到，在供体派生的Ｔ细胞淋巴瘤中，有许多数目和结构畸变。有意义的是：几乎在每组淋巴瘤中都发现了含有易位的共同畸变。如：Ｄ组中１１号和１２号染色体的易位；Ｅ组中１２号和１５号钵体的易位；Ａ组和Ｆ组中还有共同的１５号染色体三体。这些结果表明：包含易位的染色体畸变在辐射诱发淋巴瘤过程中可能是重要

Analysis of initial events in radiation-induced lymphomagenesis:investigation of chromosome aberrations including translocations

To investigate the contribution of chromosome aberrations in radiation- induced lymphomagenesis, chromosome G-banding analysis of the lymphoma cells(8 groups and 34 kinds of cells),of which each group was derived from a single donor by intrathymic injection of a limited number of prelymphoma cells, was performed.Many numerical and structural aberrations were observed in the donor-derived T cell lymphomas. Common aberrations including translocations were found almost in the lymphomas of all groups.Translocations between chromosomes 11 and 12,12 and 15,7 and 10,1 and 13, 6 and X were found in D, E, F, G,H groups,respectively.There were also common aberrations such as trisomy 15 in A and F groups.These results indicate that chromosome aberrations including translocations may be important candidates of initiating events in radiation-induced lymphomagenesis.