紫草油治疗神经内科ICU患者急性肛周湿疹的有效性和安全性

目的探讨紫草油治疗神经内科ICU患者急性肛周湿疹的有效性和安全性。方法采用便利抽样法选择120例符合急性肛周湿疹诊断标准的神经内科ICU患者,采用抽签法随机分为对照组(复合炉甘石洗剂治疗)和观察组(紫草油治疗)各60例,比较两组患者治疗的有效性(病情评分、Braden评分、治疗有效率,疗程)及安全性。结果两组患者在男女比例、年龄、原发病构成、治疗前病情评分和Braden评分方面差异无统计学意义(均P0.05)。治疗后,观察组和对照组的病情评分、Braden评分、总有效率及疗程分别为(0.60±0.99)和(1.0±0.85)、(18.37±1.38)和(14.25±1.36)、91.7%和66.7%、(3.17±2.83)d和(6.34±2.96)d,差异均有统计学意义(P0.05或P0.01);患者病情越轻,紫草油的痊愈率(Ⅰ度97.2%、Ⅱ度41.7%、Ⅲ度8.3%)和总有效率(Ⅰ度100%、Ⅱ度100%、Ⅲ度58.3%)越高,平均疗程越短[Ⅰ度(2.92±1.03)d、Ⅱ度(5.25±2.90)d、Ⅲ度(9.50±2.74)d],差异均有统计学意义(均P0.01)。两组患者均未发生明显的不良反应事件。结论紫草油治疗神经内科ICU患者急性肛周湿疹安全、有效,且治疗越早、病情越轻,则疗效越好、疗程越短。

Effectiveness and Safety of Lithospermum Oil on the Patients with Perianal Eczema in Neurological Intensive Care Unit

Objective To study the effectiveness and safety of lithospermum oil on the patients with new perianal eczema in neurological intensive care unit （NICU）. Methods By convenience sampling, a total of 120 patients in NCIU who met the criteria for perianal eczema were randomly and equally divided into the control group （compound calamine lotion） and the observational group （Iithosperrnurn oil）. The effectiveness （condition score, Braden score, onset time and efficacy indicators） and the safety between two drugs were evaluated and compared. Results There were no significant difference in gender distribution, the age of patients, the composition of original diseases, condition score and Braden score between two groups before treatment （P 〉 0. 05）. After treatment, compared to the control group, the disease related condition scores decreased significantly （0. 60±0. 99 vs 1. 0±0. 85,P=0. 012） and Braden scores increased dramatically （18. 37±1. 38 vs 14. 25±1. 36,P=0. 019） in the observational group. Total efficient rates （91. 7% vs 66.7% ,P=0. 005） of patients were statistically higher and the mean duration of therapy was much shorter [（3.17±2. 83）d vs（6. 34±2. 96）d,P=0. 001] in the obervational group than those in the control group. The lesser the perianal eczema wasv the higher the cure rates （degree I ：97.2%, II ：41. 7%, ill ：8. 3%） and the efficient rates（degree I ： 100 % , II ： 100 % , ill ： 58. 3 %） , and the shorter the duration of lithospermum oil treatment [degree I ： （2, 92±1. 03）d, II： （5. 25±2. 90）d, III： （9, 50±2. 74）d] would be（P〈0. 01）. No adverse event was observed in both groups during the whole study. Conclusion It is effective and safe to treat the patients with new perianal eczema by using lithospermum oil in NICU. The lesser the severity of new perianal eczema is, the better the curative effect, and the shorter the therapy duration will be.