| 辣椒免加热法提取物的镇痛作用研究 |
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| 引用本文： | 张莉,胡迎庆,郭鹏,高颖,陈凯,张洪,齐刚. 辣椒免加热法提取物的镇痛作用研究[J]. 时珍国医国药, 2006, 17(8): 1451-1452 |
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| 作者姓名： | 张莉 胡迎庆 郭鹏 高颖 陈凯 张洪 齐刚 |
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| 作者单位： | 1. 武警医学院药剂教研室,天津,300162
2. 武警医学院中心实验室,天津,300162 |
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| 摘 要： | 目的考察采用免加热提取工艺得到的辣椒提取物的镇痛作用强弱。方法采用小鼠热板法疼痛模型,比较免加热工艺辣椒酯提取物(EE)和水提取物(AE)灌胃给药后对小鼠痛阈的影响。结果灌胃给予小鼠EE(960,1 920 mg/kg)和AE(960,1 920,3 840 mg/kg)明显延长热板致痛小鼠的痛阈。两种提取物中960 mg/kg剂量组出现镇痛作用的时间有差异。结论免加热辣椒水提取物和酯提取物均有镇痛作用,但相同剂量下酯提取物显效较快。
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| 关 键 词： | 辣椒 镇痛 免加热法 |
| 文章编号： | 1008-0805（2006）08-1451-02 |
| 收稿时间： | 2005-06-13 |
| 修稿时间： | 2006-03-16 |
Study on Analgesic Effects of Extracts Got with Heating Free Technologies from Capsicum |
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| ZHANG Li,HU Ying-qing,GUO Peng,GAO Ying,CHEN Kai,ZHANG Hong,QI Gang. Study on Analgesic Effects of Extracts Got with Heating Free Technologies from Capsicum[J]. Lishizhen Medicine and Materia Medica Research, 2006, 17(8): 1451-1452 |
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| Authors: | ZHANG Li HU Ying-qing GUO Peng GAO Ying CHEN Kai ZHANG Hong QI Gang |
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| Abstract: | ObjectiveTo study the analgesic effects of extracts of Capsicum got with heating free technology.MethodsUsing analgestic model of hot-plate in mice.Observing the effects of the ester extract(EE) and the aqueous extract(AE)of Capsicum on latency of analgesia were observed.ResultsEE(960,1 920 mg/kg)and AE(960,1 920,3 840 mg/kg)intragastric(ig) significantly prolonged the latency of analgesia in hot-plate model in mice.But there was difference of hot-plate reaction times in EE and AE of 960mg/kg groups.ConclusionThe EE and AE of Capsicum haue analgesic effects in mice,but the analgesic effect of EE appeare faster than AE with equal dosage. |
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| Keywords: | Capsasin Analgesia Heating free technology |
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