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| 电项针疗法对脑缺血再灌注大鼠ICAM-1及ICAM-1 mRNA表达的影响 | |
| 引用本文： | 朱肖菊,王晓杰. 电项针疗法对脑缺血再灌注大鼠ICAM-1及ICAM-1 mRNA表达的影响[J]. 针灸临床杂志, 2011, 27(7): 60-62 |
| 作者姓名： | 朱肖菊 王晓杰 |
| 作者单位： | 黑龙江中医药大学,黑龙江哈尔滨,150040 |
| 摘 要： | 目的:观察电项针疗法对脑缺血再灌注后大鼠脑缺血半暗区细胞间粘附分子-1表达的影响。方法:运用栓线法制作局灶性脑缺血再灌注大鼠模型,随机将大鼠分成4组:假手术组、模型组、电体针组和电项针组,随机又将各组大鼠分为12 h、1 d、3 d和5 d共4个时点。通过HE染色的方法观察病理形态学的变化;应用免疫组织化学方法和原位杂交技术检测脑缺血半暗区ICAM-1和ICAM-1 mRNA的表达。结果:HE染色显示:与模型组相比,治疗组缺血半暗区的神经细胞肿胀程度减轻,胶质细胞增生,新生毛细血管和神经元的数量增多;电项针组明显于电体针组。治疗组可在早期抑制ICAM-1蛋白及其mRNA的表达(P<0.05,P<0.01)。同时间点电项针组与电体针组比较有显著性差异(P<0.05)。结论:电项针疗法可有效减轻神经元的损伤程度;电项针疗法可以下调再灌注后缺血区细胞间粘附分子-1蛋白及其mRNA的表达,从而达到防治脑缺血再灌注炎性损伤的目的。 |
| 关 键 词： | 电项针 脑缺血再灌注损伤 细胞间粘附分子-1 |
The Effect of Electro-nape-acupuncture on the Expression of ICAM-1 and ICAM-1m RNA of Rats with Cerebral Ischemia-reperfusion |
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| ZHU Xiao-ju,WANG Xiao-jie. The Effect of Electro-nape-acupuncture on the Expression of ICAM-1 and ICAM-1m RNA of Rats with Cerebral Ischemia-reperfusion[J]. Journal of Clinical Acupuncture and Moxibustion, 2011, 27(7): 60-62 | |
| Authors: | ZHU Xiao-ju WANG Xiao-jie |
| Affiliation: | ZHU Xiao-ju,WANG Xiao-jie(Heilongjiang University of Chinese Medicine,Harbin 150040,China) |
| Abstract: | Objective:To observe the effect of ICAM-1 by using mechanism of electro-nape-acupuncture on rats brain after acute cerebral infarction. Methods:Making rats model of brain ischemia by bolting the middle cerebral artery with monofilament.The rats were divided into four groups:fake group,pattern group,electro-acupuncture group and electro-nape-acupuncture group.The rats were randomly separated into twelve hours,one day,three days and five days.HE staining was used to observe the varies of histomorphology.To de... |
| Keywords: | Electro-nape-acupuncture Cerebral ischemia-reperfusion injury ICAM-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |