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东莨菪碱在治疗重型创伤性脑损伤中的临床疗效观察
引用本文:马班友,周继业,王寿海,葛永兴,何桂芝,尹晓红.东莨菪碱在治疗重型创伤性脑损伤中的临床疗效观察[J].中国当代医药,2010,17(31):47-48.
作者姓名:马班友  周继业  王寿海  葛永兴  何桂芝  尹晓红
作者单位:苏州大学附属常州市第四人民医院神经外科,江苏常州,213001
摘    要:目的:观察东莨菪碱治疗重型创伤性脑损伤的临床疗效,探讨提高重型创伤性脑损伤临床疗效的治疗方法。方法:选择确诊为重型创伤性脑损伤患者87例,随机分为对照组与观察组,对照组42例采用常规外科治疗,观察组45例在常规外科治疗的基础上加用东莨菪碱治疗,比较两组患者治疗后动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)及术后6个月的临床疗效。结果:观察组临床疗效好于对照组,在治疗后动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)及术后6个月的临床疗效方面比较,差异有统计学意义(P〈0.05)。结论:对重型创伤性脑损伤患者加用东莨菪碱治疗,可明显提高临床治疗效果,值得临床广泛推广。

关 键 词:东莨菪碱  重型  颅脑损伤

Clinical effects observation of scopolamine in treatment of severe traumatic brain injury
Authors:MA Banyou  ZHOU Jiye  WANG Shouhai  GE Yongxing  HE Guizhi  YIN Xiaohong
Institution:,(Department of Neurosurgery,Changzhou Tumor Hospital Affiliated to Medical School of Soochow University,Jiangsu Province,Changzhou 213001,China)
Abstract:Objective:To observe the clinical effects of Scopolamine in treatment of severe traumatic brain injury.Methods:Collected 87 patients with severe traumatic brain injury,they were randomly divided into control group and observer group,42 patients were divided into control group with general surgery treatment,45 patients were divided into observer group with general surgery and Scopolamine treatment,then compare PaO2,PaO2/FiO2 and the clinical effect after 6 months.Results:The observer group' s clinical effects was better than the control group' s,there was a statistical significance(P〈0.05) in PaO2,PaO2/FiO2 and the clinical effect after 6 months.Conclusion:Patients with severe traumatic brain injury are treated with scopolamine;it can increase the clinical effects obviously and should be widely promoted.
Keywords:Scopolamine  Severe  Head injury
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