他汀类药物的抗炎作用

近年有人提出冠状动脉粥样硬化应称为动脉粥样硬化性炎症更为确切。他汀类药物除具有明显的降脂作用 ,一些研究提示他汀类药物还具有明显的抗炎作用 ,包括抑制炎性细胞向病变处的迁移以及大量炎症因子的释放 ,抑制平滑肌细胞增殖 ,进而促进斑块稳定 ,改善血管内皮的功能 ,抑制细胞凋亡 ,降低病人急性相反应蛋白CRP的水平等作用。进而达到稳定粥样斑块 ,预防急性冠脉综合征的发生。

Anti-inflammatory Properties of Statins

These years,some people consider that coronary athe rosclerosis should be called coronary inflammation.Except statins may decrease s erum cholesterol,some studies indicate statins also have anti-inflammatory pro perties,including decreasing inflammatory cell,expression of cytokines and smoot h muscle cell proliferation in the stetosis,ameliorating endothelial cell funct ion,restraining apotosis,decreasing serum CRP.Those anti-inflammatory properti es may play an important role in preventing acute coronary syndrome.