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| miR-34a在心血管疾病中的作用及机制研究进展 | |
| 引用本文： | 李晓伟,奉淑君,周凤华,靳文,赵一俏. miR-34a在心血管疾病中的作用及机制研究进展[J]. 中国动脉硬化杂志, 2019, 27(7): 624-628 |
| 作者姓名： | 李晓伟 奉淑君 周凤华 靳文 赵一俏 |
| 作者单位： | 南华大学;南华大学教学医院广东省第二人民医院心血管内科;南华大学附属郴州医院心血管内科;南方医科大学中医药学院 |
| 基金项目： | 国家自然科学基金青年科学基金(81202951)；广东省自然科学基金(2016A030313853)；中国中青年临床研究基金(2017-CCA-VG-016)；“互联网＋专家团队”驱动的高血压分级诊疗模式示范应用(2018-TG-03) |
| 摘 要： | 微小RNA(miR)是心血管疾病发生发展的重要调控因子。其中,miR-34a因广泛参与心血管疾病的病理生理过程成为目前研究热点。在冠状动脉粥样硬化性心脏病等心血管疾病中均存在miR-34a的异常表达。本文就miR-34a对心血管疾病的作用及其机制研究进展进行综述,为寻求心血管疾病标志物及治疗靶点提供新思路。 |
| 关 键 词： | miR-34a 心血管疾病 冠状动脉粥样硬化性心脏病 |
| 收稿时间： | 2018-11-16 |
| 修稿时间： | 2019-01-24 |
Advances in miR-34a:its roles and mechanisms in cardiovascular disease |
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| LI Xiaowei,FENG Shujun,ZHOU Fenghu,JIN Wen and ZHAO Yiqiao. Advances in miR-34a:its roles and mechanisms in cardiovascular disease[J]. Chinese Journal of Arteriosclerosis, 2019, 27(7): 624-628 | |
| Authors: | LI Xiaowei FENG Shujun ZHOU Fenghu JIN Wen ZHAO Yiqiao |
| Affiliation: | University of South China, Hengyang, Hunan 421001, China;Department of Cardiology, Guangdong Second Provincial General Hospital, University of South China, Guangzhou, Guangdong 510317, China,University of South China, Hengyang, Hunan 421001, China;Department of Cardiology, the First People''s Hospital of Chenzhou, University of South China, Chenzhou, Hunan 423000, China,School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China,Department of Cardiology, Guangdong Second Provincial General Hospital, University of South China, Guangzhou, Guangdong 510317, China and Department of Cardiology, Guangdong Second Provincial General Hospital, University of South China, Guangzhou, Guangdong 510317, China |
| Abstract: | MicroRNA(miR)have been considered as the important regulators in both physiological and disease contexts, among which miR-34a has drawn great attention as its multiple functions in cardiovascular disease. It is reported that miR-34a is either upregulated or downregulated in atherosclerotic cardiovascular diseases, etc. This article reviews both the roles and mechanisms of miR-34a in cardiovascular diseases, aiming to provide new ideas for further researches on biomarkers and treatment target of cardiovascular disease. |
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