| C1q/肿瘤坏死因子相关蛋白6在肥胖及胰岛素抵抗中的研究进展 |
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| 引用本文： | 刘敏,彭铤,肖新华.C1q/肿瘤坏死因子相关蛋白6在肥胖及胰岛素抵抗中的研究进展[J].中国动脉硬化杂志,2019,27(3):264-266, 272. |
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| 作者姓名： | 刘敏 彭铤 肖新华 |
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| 作者单位： | 南华大学附属第一医院内分泌代谢科 |
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| 基金项目： | 国家自然科学基金项目(81870595)；湖南省卫计委重大专项课题(A2017011) |
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| 摘 要： | C1q/肿瘤坏死因子相关蛋白6(CTRP6)是CTRP超家族中的一员,诸多研究证明,CTRP在胰岛素抵抗及肥胖的形成中起到重要作用,因而研究其参与的作用及具体机制,有助于为胰岛素抵抗及肥胖的治疗指明方向。文章主要对CTRP6的结构、分布及其促进胰岛素抵抗与肥胖的相关生理功能的研究进展进行综述。
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| 关 键 词： | C1q/肿瘤坏死因子相关蛋白6 胰岛素抵抗 肥胖 脂肪组织炎症 |
| 收稿时间： | 2018/8/9 0:00:00 |
| 修稿时间： | 2019/1/11 0:00:00 |
Research advances of C1q/TNF-related protein-6 in obesity and insulin resistance |
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| LIU Min,PENG Ting and XIAO Xinhua.Research advances of C1q/TNF-related protein-6 in obesity and insulin resistance[J].Chinese Journal of Arteriosclerosis,2019,27(3):264-266, 272. |
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| Authors: | LIU Min PENG Ting and XIAO Xinhua |
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| Institution: | Department of Metabolism and Endocrinology, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China,Department of Metabolism and Endocrinology, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China and Department of Metabolism and Endocrinology, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China |
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| Abstract: | C1q/TNF-related protein-6 (CTRP6) is a member of the CTRP superfamily. Recently, researchers have highlighted CTRP6 as a novel adipokine that play an important role in obesity and insulin resistance (IR). Exploring the biological function and molecular mechanism of CTRP6 in adipocytes may provide a new approach to obesity-related metabolic diseases. This paper mainly reviews the research progress of the structure, distribution of CTRP6, and its biological function in the pathogenesis of IR. |
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| Keywords: | C1q/TNF-related protein-6 insulin resistance obesity adipose tissue inflammation |
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