| 压力负荷增加大鼠模型血浆内皮素水平的改变 |
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| 引用本文： | 张群燕,董晓蕾,郭郡浩,张永文,赵智明,蔡辉. 压力负荷增加大鼠模型血浆内皮素水平的改变[J]. 现代医学, 2010, 38(1): 29-32. DOI: 10.3969/j.issn.1671-7562.2010.01.008 |
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| 作者姓名： | 张群燕 董晓蕾 郭郡浩 张永文 赵智明 蔡辉 |
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| 作者单位： | 南京军区南京总医院,中西医结合科,江苏,南京,210002 |
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| 基金项目： | 南京军区南京总医院科研基金资助项目(Q2008042) |
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| 摘 要： | 目的：观察压力负荷增加对大鼠血浆内皮素水平的影响。方法：采用腹主动脉狭窄法所致压力负荷增加诱发大鼠左室肥厚模型，观察左室重量指数（LVMI），采用放射免疫分析法检测血浆内皮素水平。结果：LVMI模型组明显高于假手术组（P〈0．01）；血浆内皮素水平模型组较假手术组显著升高（P〈O．01）。结论：腹主动脉缩窄所致压力负荷增加可诱发大鼠左室肥厚，该作用可能与血浆内皮素水平升高有关。
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| 关 键 词： | 慢性心力衰竭 压力负荷 内皮素 大鼠 |
Changes of the plasma endothelin in rats with pressure overload |
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| ZHANG Qun-yan,DONG Xiao-lei,GUO Jun-hao,ZHANG Yong-wen,ZHAO Zhi-ming,CAI Hui. Changes of the plasma endothelin in rats with pressure overload[J]. Modern Medical JOurnal, 2010, 38(1): 29-32. DOI: 10.3969/j.issn.1671-7562.2010.01.008 |
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| Authors: | ZHANG Qun-yan DONG Xiao-lei GUO Jun-hao ZHANG Yong-wen ZHAO Zhi-ming CAI Hui |
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| Affiliation: | ZHANG Qun-yan,DONG Xiao-lei,GUO Jun-hao,ZHANG Yong-wen,ZHAO Zhi-ming,CAI Hui(Department of Integrated Traditional Chinese , Western Medicine,Nanjing General Hospital of Nanjing Military Comm,,PLA,Nanjing 210002,China) |
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| Abstract: | Objective: To observe the effects of pressure overload on level of plasma endothelin,and study the possible mechanism of left ventricular remodeling.Methods: left ventricular mass index(LVMI) and plasma endothelin were measured in the rat models with myocardial hypertrophy of chronic heart failure and pressure overload by abdominal aortic constriction by radioimmunoassay.Results: LVMI in the model group was obviously higher than that of the sham group(P<0.01).The plasma endothelin levels in the model group ... |
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| Keywords: | chronic heart failure pressure overload endothelin rats |
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