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| 血塞通注射液对沙土鼠脑缺血损伤的保护作用 | |
| 引用本文： | 郭泽云 武云平. 血塞通注射液对沙土鼠脑缺血损伤的保护作用[J]. 昆明医学院学报, 1999, 20(2): 1-3 |
| 作者姓名： | 郭泽云 武云平 |
| 作者单位： | 昆明医学院组胚教研室(郭泽云，李素华)，昆明医学院云南省天然药物药理重点实验室!昆明650031(武云平，李玲，陈植和，吴婉玲) |
| 基金项目： | 云南省应用基础研究基金 |
| 摘 要： | 通过夹闭沙土鼠双侧颈总动脉１０ ｍｉｎ 或２０ ｍｉｎ 后再灌７ ｄ 或１ ｄ ， 造成脑缺血再灌模型， 检测血塞通对沙土鼠脑组织钙、水含量的影响， 以及对海马 Ｃ Ａ１ 区死亡的神经元迟发性损伤的保护作用． 结果显示， 血塞通可降低缺血后脑组织钙的含量， 减少海马 Ｃ Ａ１ 区死亡的神经元数量， 增加神经元密度． 实验结果提示血塞通对脑缺血再灌损伤有一定的保护作用． |
| 关 键 词： | 脑缺血 沙土鼠 再灌 |
Effect of Ginsenoside Injection on the Cerebral Ischemia and Reperfusion in Gerbils |
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| Guo Zeyun ) Wu Yunping ) Li Suhua ) Li Ling ) Chen Zhihe ) Wu Wangling ). Effect of Ginsenoside Injection on the Cerebral Ischemia and Reperfusion in Gerbils[J]. Journal of Kunming Medical College, 1999, 20(2): 1-3 | |
| Authors: | Guo Zeyun ) Wu Yunping ) Li Suhua ) Li Ling ) Chen Zhihe ) Wu Wangling ) |
| Affiliation: | Guo Zeyun 1) Wu Yunping 2) Li Suhua 1) Li Ling 2) Chen Zhihe 2) Wu Wangling 2) |
| Abstract: | The model of cerebral ischemia and reperfusion in gerbils was induced by bilateral carotid arteries occluded for 10 min or 20 min follwed by 7-day or 1-day reperfusion. The effect of ginsenoside injection on the content of calcium, water in brain and the density of neuron in hippocampal CA 1 sector was observed. The results showed that ginsenoside injection could decrease the content of calcium in brain and increase the density of neuron in hippocampal CA 1 sector. It suggests that gingenoside injection has a protective effect on cerebral ischemia and reperfusion injury. |
| Keywords: | Cerebral ischemia Gerbils Reperfusion |
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