柔性可延展能量收集装置的心脏表面缝合实验研究

目的：近年来，以纳米技术制造柔性可延能量收集装置（ ultra－flexible energy harvester， UFEH）为能源的供应方法提供了新的思路。利用动物实验验证此类材料在生物体内的大范围应用需通过动物实验进行相容性验证。方法通过小型猪动物实验，研究UFEH在生物体内的工作状态，通过家兔对比实验，验证长期佩戴时生物体内相容性。结果于小型猪实验中，器件贴合良好，工作状态符合设计要求，贴合前后实验动物心功能相同，最高输出电压可达3V。在家兔对照实验中，实验组家兔存活时间与对照组一致，各项生理指标正常，未出现意外死亡、瘫痪、心功能下降等。结论压电设备于生物体内运行正常，对生物体组织伤害小，输出电压可达到商用级别；但仍需通过结合不同医用材料并对设备进行升级完善，可逐步完成生物体内长期植入目的。柔性可延展压电设备为体内收集机械能提供了新的思路与新的方法，符合我国自主创新的研究方向，为今后逐步实现能源清洁化，医用设备能源自给提供了可靠思路。

Ultra-Flexible Energy Harvester:in vivo Testing on Epicardium

Objective Ultra-flexible energy harvester (UFEH) is a kind of new energy resources based on piezoelectric theory.The biocompatibility of these materials should be proved through experiment.Methods We validate the biocompatibility of piezoelectric materials through experimental swine to establish an animal model; and we would also compare the different status of experimental rabbits before and after the device implantation to reveal long-term impact.Results The results showed that UFEH could appropriately fit the swine's heart and the peak-to-peak voltage can reach as high as 3V.The control experiment revealed that there were no significant differences between device implantation group and the cases under normal thoracotomy.Conclusion UFEH implantation was safe and efficacy with less damage to animal tissues and the output voltage could also meet the needs of clinical requirements.Piezoelectric materials were proved to be a new source of energy harvest and deserve further attention toward medical usage.