同时放—化疗治疗晚期鼻咽癌临床观察

本研究目的在于探讨同时放化疗治疗晚期鼻咽癌（全部患者为Ｎ２，Ｎ３期）疗效和毒性反应，从１９９４年１０月到１９９６年９月，４３例晚期鼻咽癌接受同时放化疗（实验组）治疗。化疗采用ＤＤＰ加５－Ｆｕ分别于放疗过程第１～２周和第５～６周进行，每周２，５各１次，ＤＤＰ总量２００～３００ｍｇ，５－Ｆｕ为６０００～８２５０ｍｇ配对抽取单纯放疗患者４３例供疗效对比观察，治疗结束时，实验组颈淋巴消退率８１．４％，优于

Concurrent radio-chemotherapy for advanecd nasopharyngeal carcinoma

This clinical trial was designed to evaluate the efficacy and toxicity of combination radio-therapy (RT) with chemotherapy (CT) in treating thepatients with advanced NPC (all patients with N2~N3 stage). From Oct. 1994 to Sept. 1996, 43 patientswith advanced NPC were treated by concurrent RT~CT (study group). From the first to second weekthen from fifth to sixth week, DDP plus 5-Fu weregiven on Tuesday and Friday weekly during the radiation course. The total cumulative dose of DDP variedfrom 200~300mg, and 5-Fu varied from 6000 ~8250mg. 43 matched patients received RT alone (control group). At the end of treatment, the regrressiverates of cervical nodes were 81. 4% in study group,and 53. 5% in control group (P<0. 05). The 12month distant metastasis rates was 14% for studygroup versus 32. Sa for control group (P <0. 05)The l-year survival rates were 98% in study groupand 86 % in control group, with significent differencebetween the groups (P<0. 05).The major toxic effects of CT were nausea, vomiting and acute severe mucositis. RT was interruptedin one case for ten days in study sroup. Most patientscan complete the planned RT. The author concludedthat the combination of RT-CT is an effective andsafe treatment in patients with advanced NPC.