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| 32例产甲胎蛋白胃癌回顾性分析 | |
| 引用本文： | 田蓝天,姚珂,吴傲,李龙,张志程,裴铁民,刘连新. 32例产甲胎蛋白胃癌回顾性分析[J]. 中国现代普通外科进展, 2011, 14(6): 441-445,453. DOI: 10.3969/j.issn.1009-9905.2011.06.006 |
| 作者姓名： | 田蓝天 姚珂 吴傲 李龙 张志程 裴铁民 刘连新 |
| 作者单位： | 1. 哈尔滨医科大学附属第一医院 普通外科 2. 哈尔滨医科大学附属第一医院 病理科 黑龙江哈尔滨150001 3. 山东省巨野县人民医院急诊科 山东菏泽274900 |
| 基金项目： | 黑龙江省杰出青年科学基金(JC200616) |
| 摘 要： | 目的：探讨产甲胎蛋白胃癌（α-fetoprotein-producing gastric carcinoma,AFPGC）的临床病理学特征、治疗及预后影响因素。方法：回顾分析2001年1月—2007年1月在哈尔滨医科大学附属第一医院确诊并完成治疗的468例胃癌患者住院病案资料,发现血清AFP升高患者67例,排除肝硬化、肝脏肿瘤、生殖系统肿瘤等因素后,最终确诊为AFPGC患者32例。调阅该32例患者的临床诊疗及随访资料,统计处理相关实验室及随访数据结果。结果：AFPGC患者占同期胃癌患者的6.8%（32/468）。与非AFPGC患者相比,AFPGC具有更高的淋巴结转移率（P=0.025）和肝脏转移率（P=0.011）。目前常用化疗方案不能有效控制疾病进展,32例AFPGC患者中20例最终死于肝转移,平均生存时间35.7个月。结论：AFPGC具有高度侵袭性,易发生肝转移,预后差。治疗首选胃癌根治术,术后进行辅助化疗。 |
| 关 键 词： | 胃肿瘤,产甲胎蛋白 病理学特征 化疗 预后 |
Retrospective analysis of 32 alpha-fetoprotein-producing gastric cancer |
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| TIAN Lan-tian,YAO Ke,WU Ao,LI Long,ZHANG Zhi-cheng,PEI Tie-min,LIU Lian-xin. Retrospective analysis of 32 alpha-fetoprotein-producing gastric cancer[J]. Chinese Journal of Current Advances in General Surgery, 2011, 14(6): 441-445,453. DOI: 10.3969/j.issn.1009-9905.2011.06.006 | |
| Authors: | TIAN Lan-tian YAO Ke WU Ao LI Long ZHANG Zhi-cheng PEI Tie-min LIU Lian-xin |
| Affiliation: | TIAN Lan-tian1,YAO Ke2,WU Ao3,LI Long1,ZHANG Zhi-cheng1,PEI Tie-min1,LIU Lian-xin11Department of General Surgery,2Department of Pathology,the First Affiliated Hospital of Harbin Medical Univesity(Harbin 150001,China)3Emergency Department,the People's Hospital of Juye County,Shandong Province(He ze 274900,China) |
| Abstract: | Objective:To investigate the clinicopathologic characteristics,treatments and prognostic factors of AFPGC.Methods: 468 gastric cancer medical files preserved at the medical record library were retrospectively reviewed.There were 67 patients with elevated serum level of AFP among these patients who were made a definite diagnosis of gastric cancer and subsequently received surgery and systemic combined therapy at the First Affiliated Hospital of Haerbin Medical University(FAHHMU) between January 2001 and Janu... |
| Keywords: | Stomach neoplasm α-protein-producing·Pathological features·Chemotherapy·Prognosis |
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