Association between circadian rhythm of blood pressure and glucose tolerance status in normotensive,non-diabetic subjects |
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| Affiliation: | 1. Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand;2. First Hospital of Tsinghua University, Beijing, China;3. Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand;1. Sustainable Aquaculture Laboratory – Temperate and Tropical (SALTT), School of BioSciences, University of Melbourne, Victoria 3010, Australia;2. Institute of Marine Research, Matre Research Station, 5984 Matredal, Norway;1. Centre de recherche Inserm, U897, Univ Victor Segalen, Bordeaux, France;2. Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico;1. Department of Clinical Science, University of Bergen, Jonas Lies veg 87, 5021 Bergen, Norway;2. Core Facility for Metabolomics, University of Bergen, Jonas Lies veg 87, 5021, Bergen, Norway;3. Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Institute of Biology II, Strada Le Grazie 8, 37134 Verona, Italy;4. Department of Occupational Medicine, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway;5. Centre for International Health, University of Bergen, Jekteviksbakken 31, 5009 Bergen Bergen, Norway;6. Faculty of Medicine, University of Iceland, Reykjavik, Iceland;7. Department of Pulmonology - Division of Allergy, University Hospital of Montpellier, University Montpellier, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier, France;8. Sorbonne University, French National Institute of Health and Medical Research, Pierre Louis Institute of Epidemiology and Public Health, 56 Boulevard Vincent-Auriol, 75646 Paris, France;9. Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, 207 Bouverie Street, 3052 Carlton, Australia;10. Department of Surgical and Perioperative Sciences, Surgery, Umea University, Koksvagen 11, 90185 Umea, Sweden;11. ISGlobal, Doctor Aiguader 88, 08003 Barcelona, Spain;12. University Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Spain;13. CIBER Epidemiology and Public Health, Doctor Aiguader 88, 08003 Barcelona, Spain;14. Pneumology Department University Hospital San Agustín, Camino Heros 4, 33410, Avilés, Spain;15. Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilian University Munich, Ziemssenstrasse 1, 80336 Munich, Germany;p. Department of Occupational and Environmental Medicine, University of Gothenburg, Medicinaregatan 16A, 41390 Gothenburg, Sweden;q. National Heart and Lung Institute, 1b Manresa Road SW3 6LR, Imperial College, London, United Kingdom;r. Department of Lung Medicine, Tartu University Hospital, Lung Clinic, Riia 167, Tartu 51014, Estonia;s. Department of Medical Sciences, Respiratory, allergy and sleep research, Uppsala University, Akademiska sjukhuset Ing. 40, Uppsala, Sweden;t. Pulmonology Service, Albacete University Hospital Complex, Health Service of Castilla - La Mancha, Albacete, Spain;u. Faculty of Medicine of Albacete, Castilla-La Mancha University, Albacete, Spain;v. Unit of Epidemiology and Public Health, Department of Health, Basque Government, Alameda Rekalde 39A, 48008 Bilbao, Spain;w. Department of Pediatrics, University Hospital Grenoble Alpes, French National Institute of Health and Medical Research, Institute for Advanced Biosciences, University Grenoble Alpes, CS 10217, 38043 Grenoble cedex 9, France;x. Swiss Tropical and Public Health Institute, Socinstrasse 58, 4002 Basel, Switzerland;y. Department of Public Health, University of Basel, Petersplatz 1, 4001 Basel, Switzerland;z. U1219, Bordeaux Population Health Research, Bordeaux University, 146 rue Leo Saignat, 33076 Bordeaux, France;1. Department of Nursing, University of Huelva, Avenida Tres de Marzo, s/n 21071, Huelva, Spain;2. Department of Public Health, Aarhus University, Bartholins Alle 2, 8000 Aarhus, Denmark;3. National Research Centre for the Working Environment, Lersø Parkalle 105, 2100 Copenhagen, Denmark;4. Team of Epidemiology, French National Institute of Health and Medical Research UMR1152, Paris, France;5. Department of Gynecology and Obstetrics, Haukeland University Hospital, Jonas Lies veg 65, 5021 Bergen, Norway |
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| Abstract: | AimsTo examine whether circadian rhythm of blood pressure (BP) is associated with glucose tolerance status in normotensive, non-diabetic subjects.MethodsA cross-sectional study recruited normotensive and non-diabetic subjects, aged 35–79 years. A 75 g oral glucose tolerance test (OGTT) and 24-h ambulatory blood pressure monitoring (24-h ABPM) were performed.ResultsAmong 31 impaired glucose tolerance (IGT) and 36 normal glucose tolerance (NGT) study subjects, the mean (±S.D.) diurnal–nocturnal differences of average systolic BP (SBP) were 7.1 ± 6.9 and 9.9 ± 6.2 mm Hg, respectively (p = 0.086). In a linear mixed-effects regression model, however, taking each measurement of BP as the outcome, nighttime reduction of SBP in the IGT group was 7.19 mm Hg, which was significantly smaller compared to a reduction of 9.80 mm Hg in the NGT group (p-value for IGT: nighttime interaction = 0.0014). The prevalence of non-dipping BP pattern was 77.4% in the IGT group which was significantly higher than 52.8% of the NGT group (p = 0.036). Logistic regression revealed a significant effect of IGT for predicting non-dipping pattern with an adjusted odds ratio of 3.71 (95% CI: 1.09, 12.66, p = 0.029).ConclusionsAmong normotensive, non-diabetic subjects, the decreased nocturnal BP reduction was associated with impaired glucose tolerance status. |
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