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| 狼疮性肾炎血管病变与抗心磷脂抗体相关性研究 | |
| 引用本文： | 滕舰,林淑华,袁东. 狼疮性肾炎血管病变与抗心磷脂抗体相关性研究[J]. 泰山医学院学报, 2009, 30(2) |
| 作者姓名： | 滕舰 林淑华 袁东 |
| 作者单位： | 泰山医学院附属烟台山医院肾内科,山东,烟台,264001 |
| 摘 要： | 目的探讨狼疮性肾炎(lupus hephritis,LN)病人血管病变与血抗心磷脂抗体阳性是否具有相关性。方法随机选择2005年9月至2008年9月于我院治疗的、ANCA检测阴性的狼疮性肾炎病人60例,对肾组织行HE、PAS、PASM、Masson及IgG、IgA、IgE、C3、C4、C1q等免疫组化染色,根据其病理特点进行光镜下狼疮性肾炎分型,包括II型、III型、IV型、V型、V+III型、V+IV型,并比较光镜下肾小球、肾血管病变类型、程度及血栓情况。对每位肾活检狼疮性肾炎病人予抗心磷脂抗体检测,同时检测ANA、ds-DNA、体液免疫系列、尿蛋白、尿沉渣、肾功能、血常规等。按抗心磷脂抗体阳性、阴性将病人分为两组,比较两组病人肾脏血管病变、临床表现及ANA、ds-DNA、体液免疫系列、补体等,进行统计学分析。结果①60例LN患者中23例(38.3%)抗心磷脂抗体阳性,而阳性患者中肾脏病理检查发现15例(65.2%)存在急慢性血管病变,包括纤维素样变性、内皮肿胀、动脉血栓、内膜增厚、透明变性、弹力层分层等。另外37例(61.7%)心磷脂抗体阴性患者中14例(37.8%)存在血管病变。②两组间ANA、体液免疫... |
| 关 键 词： | 狼疮性肾炎 血管病变 抗心磷脂抗体 |
Study on the correlation of anticardiolipin antibodies and renal vascular lesions in patients with lupus nephritis |
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| TENG Jian,LIN Shu-hua,YUAN Dong. Study on the correlation of anticardiolipin antibodies and renal vascular lesions in patients with lupus nephritis[J]. Journal of Taishan Medical College, 2009, 30(2) | |
| Authors: | TENG Jian LIN Shu-hua YUAN Dong |
| Affiliation: | TENG Jian; LIN Shu-hua; YUAN Dong(Dept.of Nephrology; Yantaishan Hospital; Yantai 264001; China); |
| Abstract: | Objective: To determine the correlation of positive anticarciolipin antibody and renal vascular lesions in the patients with lupus nephritis.Methods: Sixty lupus nephritis patients with negative antineutrophil cytoplasmic antibody in Yantaishan Hospital from 2005 to 2008 were randomly recruited.Renal biopsy examination was taken in the patients.The renal specimens were stained by means of HE,PAS,PASM,Masson and checked by immunohistochemistry,and were categorized according to 2003 ISN/RPS classification as ... |
| Keywords: | lupus nephritis vascular lesion anticardiolipin（ACA） |
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