原发性肾病综合征患儿血及尿白细胞介素—18检测及其意义

目的 :探讨白细胞介素 - 1 8(IL - 1 8)与小儿原发性肾病综合征 (PNS)发病之间的关系。方法 :采用酶联免疫吸附试验 (ELISA)测定PNS患儿极期及恢复期血、尿中IL - 1 8水平 ,并分析与 2 4h尿蛋白定量之间的关系。结果 :PNS患儿治疗前和恢复期血与尿IL - 1 8差异极为显著 ;血IL - 1 8、尿IL - 1 8均与 2 4h尿蛋白定量呈显著正相关(r =0 75 9,P <0 0 0 5 ;r=0 835 ,P <0 0 0 1 )。结论 :IL - 1 8与PNS的发病有关 ,可能在其发病中起部分作用

Itenleukin-18 levels of serum and urine in children with primary nephrotic syndrome and its significance

Objective:To investigate the relationship between the interleukin-18(IL-18)and pathogenesis of primary nephrotic syndrome(PNS)in children.Methods:The IL-18 levels of serum and urine were measured by enzyme-linked immunosorbent assay(ELISA)in 13 children with PNS who were in both a stable and active conditions and 15 healthy children.The correlations between the IL-18 of serum or urine and protein of urine in 24 hours were analysed respectively.Results:IL-18 levels of active phase in serum and urine were significantly higher than those of stable phase (P<0 001);There was a positive correlation between the IL-18 levels in serum(r=0 759,P<0 005)and urine(r=0 835,P<0 001)and protein of urine in 24 hours.Conclusions:The IL-18 levels of serum and urine were increased in PNS children and these increases were related with the activity of this disease.IL-18 may play a partial role in the pathogensis of PNS.