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| Three-Dimensional Conformal Radiotherapy for Rectal Cancer and the Changes in Cancer Multi-biomarkers | |
| 引用本文： | Rui Wei Yangde Zhang Jiantai He Liangfang Shen Jidong Hong Haijun Wu. Three-Dimensional Conformal Radiotherapy for Rectal Cancer and the Changes in Cancer Multi-biomarkers[J]. 中国肿瘤临床(英文版), 2007, 4(6): 411-415. DOI: 10.1007/s11805-007-0411-2 |
| 作者姓名： | Rui Wei Yangde Zhang Jiantai He Liangfang Shen Jidong Hong Haijun Wu |
| 作者单位： | [1]Department of Oncology, Xingya Hospital,Central South University, Changsha 410008China [2]Central South University ＆ Research Centerfor Hepatic, Biliary and Intestinal Diseases,the Ministry of Public Health, PR China |
| 基金项目： | This work was supported by a grant from Scientific Foundation of the Health Department,Hunan Provence(No.B2004-038). |
| 摘 要： | OBJECTIVE To investigate the clinical efficacy of three-dimensional conformal radiotherapy(3D-CRT)for local y advanced or postoperatively relapsed rectal cancer,and to examine the changes in cancer multi-biomarkers. METHODS Sixty patients with locally advanced or postoperatively relapsed rectal cancer were randomly divided into two groups after 40 Gy external radiation,namely a late-course 3D-CRT group and a conventional radiotherapy group that served as the control.There were 30 patients in each group.For patients in the 3D-CRT group,multi-biomarkers were measured before and after radiotherapy and after relapse. RESULTS Response rates in the 3D-CRT and the control groups were 86.7%(26/30)and 70%(21/30)respectively,without a significant difference (P>0.05).The 1-,2-and 3-year survival rates were 80%,53.3%and 36.7% in the 3D-CRT group;in the control group the rates were 56.7%,40%and 13.3%respectively,with a significant difference(P=0.0213).CEA,CA19-9, CA242 and FER decreased after radiotherapy in the 3D-CRT group,P<0.01, indicating a significant difference.The values after relapse were higher than those without relapse,P<0.01,indicating a significant difference. CONCLUSION Conventional radiotherapy with a 3D-CRT boost gives better therapeutic effect to patients with locally advanced or postoperatively local y relapsed rectal cancer.A multi-biomarker protein chip diagnosis system can be utilized as an effective tool to determine the therapeutic effect and prognosis. |
| 关 键 词： | 直肠癌 生物标记物 放射治疗 临床表现 |
| 收稿时间： | 2007-07-04 |
| 修稿时间： | 2007-11-20 |
Three-dimensional conformal radiotherapy for rectal cancer and the changes in cancer multi-biomarkers |
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| Rui Wei,Yangde Zhang,Jiantai He,Liangfang Shen,Jidong Hong,Haijun Wu. Three-dimensional conformal radiotherapy for rectal cancer and the changes in cancer multi-biomarkers[J]. Chinese Journal of Clinical Oncology, 2007, 4(6): 411-415. DOI: 10.1007/s11805-007-0411-2 | |
| Authors: | Rui Wei Yangde Zhang Jiantai He Liangfang Shen Jidong Hong Haijun Wu |
| Affiliation: | 1. Department of Oncology, Xingya Hospital,Central South University, Changsha 410008,China 2. Central South University & Research Center for Hepatic, Biliary and Intestinal Diseases,the Ministry of Public Health, PR China |
| Abstract: | OBJECTIVE To investigate the clinical efficacy of three-dimensional conformal radiotherapy(3D-CRT)for local y advanced or postoperatively relapsed rectal cancer,and to examine the changes in cancer multi-biomarkers. METHODS Sixty patients with locally advanced or postoperatively relapsed rectal cancer were randomly divided into two groups after 40 Gy external radiation,namely a late-course 3D-CRT group and a conventional radiotherapy group that served as the control.There were 30 patients in each group.For patients in the 3D-CRT group,multi-biomarkers were measured before and after radiotherapy and after relapse. RESULTS Response rates in the 3D-CRT and the control groups were 86.7%(26/30)and 70%(21/30)respectively,without a significant difference (P>0.05).The 1-,2-and 3-year survival rates were 80%,53.3%and 36.7% in the 3D-CRT group;in the control group the rates were 56.7%,40%and 13.3%respectively,with a significant difference(P=0.0213).CEA,CA19-9, CA242 and FER decreased after radiotherapy in the 3D-CRT group,P<0.01, indicating a significant difference.The values after relapse were higher than those without relapse,P<0.01,indicating a significant difference. CONCLUSION Conventional radiotherapy with a 3D-CRT boost gives better therapeutic effect to patients with locally advanced or postoperatively local y relapsed rectal cancer.A multi-biomarker protein chip diagnosis system can be utilized as an effective tool to determine the therapeutic effect and prognosis. |
| Keywords: | rectal cancer three-dimensional conformal radiotherapy tumor biomarker. |
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