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| 脑血疏通对实验性血管性痴呆大鼠脑内P53mRNA和HSP70mRNA表达的影响 | |
| 引用本文： | 顼宝玉,谢道珍,史大卓,尹太英. 脑血疏通对实验性血管性痴呆大鼠脑内P53mRNA和HSP70mRNA表达的影响[J]. 中国实验方剂学杂志, 1998, 4(4): 33-36 |
| 作者姓名： | 顼宝玉 谢道珍 史大卓 尹太英 |
| 作者单位： | 中国中医研究院西苑医院;北京100091 |
| 摘 要： | 用左心室注射石蜡油造成多发性梗塞的动物模型，采用组织原位要交技术及生物医学图像分析技术，测定了ＶａＤ大鼠脑内Ｐ５３ｍＲＮＡ、ＨＳＨ７０ｍＲＮＡ的表达水平，结果显示脑血疏通可通过减弱Ｐ５３ｍＲＮＡ的表达，促进ＨＳＰ７０ｍＲＮＡ表达，起到加速修复，保护脑缺血元的作用。 |
| 关 键 词： | 脑血疏通 原位杂交 血管性痴呆 基因表达 |
The Effect of Naoxie Shutong Oral Liquid on P53 and HSP70 Gene Expression in Brain Tissue in Rats with Experimental Vascular Dementia |
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| Xu Baoyu,Xie Daozhen,Shi Dazhuo,Yin Taiying. The Effect of Naoxie Shutong Oral Liquid on P53 and HSP70 Gene Expression in Brain Tissue in Rats with Experimental Vascular Dementia[J]. China Journal of Experimental Traditional Medical Formulae, 1998, 4(4): 33-36 | |
| Authors: | Xu Baoyu Xie Daozhen Shi Dazhuo Yin Taiying |
| Affiliation: | Xiyuan Hospital,China Academy of TCM,Beijing,100091 |
| Abstract: | The in situ hybridization and biomedical image pattern analysis were applied in this experiment to examine P53 mRNA and HSP70 mRNA expression level in vascular dementia (VaD)of brain tissue in rats with MID produced by injecting paraffin oil to left ventricle.The result showed that Naoxie Shutong oral liquid(NXST)can improve the expression of HSP70 mRNA by diminishing the expression of P53 mRNA,leading to accelerating recovery and protecting the ischemic neuron of brain tissue. |
| Keywords: | NXST in situ hybridization gene expression |
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