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新城疫病毒处理瘤细胞的免疫实验研究
引用本文:白艳婷 张丽娜. 新城疫病毒处理瘤细胞的免疫实验研究[J]. 四川肿瘤防治, 2000, 13(3): 148-149
作者姓名:白艳婷 张丽娜
作者单位:成都军区总医院!成都610083
摘    要:
目的:观察新城疫病毒(简称NDV)对体外培养的肿瘤细胞免疫原性的影响。方法:将经新城疫病毒处理的小鼠肝癌细胞H22为活瘤进行免疫接种。结果:NDV处理瘤细胞制备的瘤苗可完全排斥再次接种未经病毒处理瘤细胞的生长,瘤苗能增强小鼠体内细胞免疫。结论:NDV处理后的瘤细胞能使肿瘤生长减慢、荷瘤生存期明显延长。

关 键 词:新城疫病毒 肝癌细胞 免疫治疗

Immunal study on mice H_(22) hepatic carcinoma cellsinfected with newcastle disease virus
BAI Yan_ting,ZHANG Li_na,PAN Su_qiong,et alChengdu general hospital of PLA,Chengdu. Immunal study on mice H_(22) hepatic carcinoma cellsinfected with newcastle disease virus[J]. Sichuan Journal of Cancer Control, 2000, 13(3): 148-149
Authors:BAI Yan_ting  ZHANG Li_na  PAN Su_qiong  et alChengdu general hospital of PLA  Chengdu
Affiliation:BAI Yan_ting,ZHANG Li_na,PAN Su_qiong,et alChengdu general hospital of PLA,Chengdu 610083
Abstract:
Objective:To observe the effect of Newcastle Disease Virus(NDV) on the immunogenicity of in vitro tumor cells.Methods:Mice were vaccinated with live tumor vaccine of NDV pretreated mice hepatic cancer cell H22.Result:The tumor vaccine,which was made of NDV pretreated tumor cells,could reject the growth of nonpretreated tumor cells which was vaccinated subsequently.And this study also showed that the tumor vaccine could promote the cellular immunity of mice in vivo.Conclusion:NDV pretreated tumor vaccine can decrease the speed of tumor growth,and prolong the tumor_bearing survival time.
Keywords:Newcastle disease virus  Hepatic cancer cell  Immunologic therapy
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