Pulmonary infection with capsule-deficientCryptococcus neoformans |
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| Authors: | Sally A Harding W Michael Scheld Philip S Feldman Merle A Sande |
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| Institution: | (1) Departments of Pathology and Medicine, University of Virginia School of Medicine, 22908 Charlottesville, Virginia, USA |
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| Abstract: | Summary A case of bilateral lobar pneumonia due toCryptococcus neoformans is presented. The capsule-deficient fungal organisms within tissue were suggestive ofHistoplasma capsulatum. Cultures grewCryptococcus neoformans and there was cryptococcal antigen in the serum. Pulmonary cryptococcosis and the occurrence of unencapsulated cryptococci are reviewed. The important role both culture and the latex agglutination test for cryptococcal antigen play in the differential diagnosis of systemic fungal infections with over-lapping histopathology are discussed. |
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| Keywords: | Capsule deficientCryptococcus neoformans Pulmonary cryptococcosis Pulmonary fungal infection Morphologic overlap in fungi |
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