|
|||||
|
|
| Changes of osteocalcin and IGF-I during bone lengthening | |
| 引用本文： | 王兵,刘贻运,郑介柏,袁士翔,陈国勋. Changes of osteocalcin and IGF-I during bone lengthening[J]. 中华创伤杂志(英文版), 2005, 8(3): 151-155 |
| 作者姓名： | 王兵 刘贻运 郑介柏 袁士翔 陈国勋 |
| 作者单位： | Department of Orthopedics of 12th Hospital of Guangzhou，Guangdong 510620，China，Department of Orthopedics of 12th Hospital of Guangzhou，Guangdong 510620，China，Department of Orthopedics of 12th Hospital of Guangzhou，Guangdong 510620，China，Department of Orthopedics of 12th Hospital of Guangzhou，Guangdong 510620，China，Department of Orthopedics of 12th Hospital of Guangzhou，Guangdong 510620，China |
| 摘 要： | Bonelengtheningisamuchmorecomplexprocesscomparedwiththeprocessoffracturehealing.Inthisprocessbonechangesinvariousaspects,morphologicallyandphysico chemically,andat differentintervalsanddifferentlevelsoflengthening, fromgrosstoultrastructural.Themajorityofstudies havebeenfocusedonclinicalorhistologicalchanges andmorphologicalaspects.Essentiallywehavenot paidmuchattentioninascertainingthechanges,ifit hasany,whichoccurinbasicphysicalandchemical parametersofboneatdifferenttimeorregion.As evidences… |
| 关 键 词： | 胰岛素样生长因子I 骨延长 康复治疗 病理机制 |
Changes of osteocalcin and IGF-I during bone lengthening |
|
| WANG Bing,LIU Yi-yun,ZHENG Jie-bai,YUAN Shi-xiang,CHEN Guo-xun. Changes of osteocalcin and IGF-I during bone lengthening[J]. Chinese journal of traumatology, 2005, 8(3): 151-155 | |
| Authors: | WANG Bing LIU Yi-yun ZHENG Jie-bai YUAN Shi-xiang CHEN Guo-xun |
| Affiliation: | Department of Orthopedics of 12th Hospital of Guangzhou, Guangdong 510620, China |
| Abstract: | Objective: To examine the changes of osteocalcin and insulin-like growth factor I (IGF-I) during bone lengthening, and to clarify the mechanism of bone healing. Methods: Thirty-two shepherd dogs were divided into five groups randomly. Their tibiae were lengthened by Ilvzarov's external fixator at the rate of 1 mm/day. The lengthening area was the experimental side and the opposite side was the control. Samples were obtained on the 2nd, 4th, 6th, 8th, 12th weekend respectively. The samples were defatted, dried, powdered, centrifuged and measured by radioimmunoassay. Results: The osteocalcin concentration increased at the subsequent periods, but it was significantly lower in the experimental side than that of the control side, P<(0.05) and the IGF-I concentration was not significantly lowered. Conclusions: Different noncollagenous bone growth factors may be different at different stage. |
| Keywords: | Bone lengthening Osteocalcin Insulin-like growth factor I |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |