早期食管癌和高级别上皮内瘤变行内镜黏膜下剥离术后非治愈性切除的危险因素探讨

目的 探讨早期食管癌和高级别上皮内瘤变行内镜黏膜下剥离术(ESD)后非治愈性切除的危险因素.方法 回顾性分析南京医科大学附属淮安第一医院消化内科收治的153例行ESD的早期食管癌和高级别上皮内瘤变患者的临床资料,根据术后病理结果,分为治愈性切除组和非治愈性切除组,对可能影响非治愈性切除的相关因素进行多因素分析.结果 早...

Discussion of risk factors for non-curative resection after endoscopic submucosal dissection for early esophageal cancer and high-grade intraepithelial neoplasia

Objective To investigate the possible risk factors for non-curative resection after endoscopic submucosal dissection for early esophageal cancer and high-grade intraepithelial neoplasia.Methods The clinical data of 153 patients with early esophageal cancer and high-grade intraepithelial neoplasia treated by endoscopic submucosal dissection were retrospectively analyzed. According to the postoperative pathological results, they were divided into the curative resection group and non-curative resection group, and a multivariate analysis was performed to determine the factors that might influence noncurative resection.Results Early esophageal cancer, submucosal infiltration of the lesion, and poor intraoperative lesion lift were risk factors for non-curative resection after ESD for early esophageal cancer and high-grade intraepithelial neoplasia (P < 0.05). Multivariate analysis showed that the lesions were early esophageal cancer, the existence of submucosal infiltration was the independent risk factors for non-curative resection after ESD for early esophageal cancer and high-grade intraepithelial neoplasia (P < 0.05).Conclusion Early esophageal cancer, submucosal invasion of the lesion, and poor intraoperative lesion lift are risk factors for non-curable resection after early esophageal cancer and high-grade intraepithelial neoplasia. Among them, early esophageal cancer and the presence of submucosal infiltration were independent risk factors for non-curative resection.