| 大鼠臂旁核内微注射GABA对血压和心率的影响 |
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| 引用本文： | 刘长金,杨丽敏,黄承钧. 大鼠臂旁核内微注射GABA对血压和心率的影响[J]. 华中科技大学学报(医学版), 2000, 29(5): 391-393 |
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| 作者姓名： | 刘长金 杨丽敏 黄承钧 |
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| 作者单位： | 同济医科大学基础医学院生理学教研室，武汉 430030 |
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| 摘 要： | 实验在31只乌拉坦麻醉，琥珀酰胆碱肌松、人工呼吸的大鼠上进行。观察到臂旁核注入γ-氨基丁酸(GABA)，引起平均动脉压(MAP)显著降低(P<0．001)；臂旁核内注入荷包牡丹碱(Bic)引起MAP显著升高(P<0．001)；GABA的降压效应可被臂旁核内预注射Bic所阻断。上述药物在臂旁核均对心率无明显影响(P>o．05)。结果表明GABA在臂旁核内引起降压效应；臂旁核的内源性GABA具有紧张性降压作用，并参与正常血压水平的维持。
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| 关 键 词： | 臂旁核；γ-氨基丁酸；荷包牡丹碱；平均动脉压；心率 |
| 修稿时间： | 1999-10-15 |
Effect of Microinjection of GABA into Parabrachial Nuclei in Rats on Blood Pressure and Heart Rate |
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| LIU Changjin,Yang Limin,Huang Chengjun. Effect of Microinjection of GABA into Parabrachial Nuclei in Rats on Blood Pressure and Heart Rate[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2000, 29(5): 391-393 |
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| Authors: | LIU Changjin Yang Limin Huang Chengjun |
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| Abstract: | Experiments were carried out in 31 urethane anesthetized, Suxamethonium chloride paralyzed and artificially ventilated rats. The results were as follows: microinjection of γ-amino butyric acid (GABA) into parabrachial nuclei (NPB) markedly decreased the mean arterial pressure (MAP) (P＜0. 001), while the microinjection of bicuculine (Bic) into NPB caused a significant increase in MAP (P＜0. 001). The depressor effect of GABA could be blocked by preinjection of Bic in NPB. The above agents microinjected into NPB had no significant effect on heart rate (P＞0. 05). The results indicated that: (1) GABA in NPB exerts tonic depressor effect; (2) Endogenous GABA in NPB exerts tonic depressor action and takes part in maintenance of normal blood pressure level. |
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| Keywords: | parabrachial nucleus Y-amino butyric acid bicuculine mean arterial pressure heart rate |
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