| 动脉灌注化疗对局部晚期鼻咽癌的近期疗效 |
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| 引用本文： | 陈建武,张幸平,刘德鑫,肖丽华,吴敏,苏菁菁,郑建清.动脉灌注化疗对局部晚期鼻咽癌的近期疗效[J].安徽医科大学学报,2015(11). |
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| 作者姓名： | 陈建武 张幸平 刘德鑫 肖丽华 吴敏 苏菁菁 郑建清 |
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| 作者单位： | 1. 福建医科大学附属第二医院放疗科,泉州,362000;2. 重庆医科大学附属第一医院肿瘤科,重庆,400016;3. 福建医科大学附属第二医院放射科,泉州,362000 |
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| 基金项目： | 福建省自然科学基金(编号2011J01155)；福建省医学创新课题(编号2009cx-10) |
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| 摘 要： | 将局部晚期鼻咽癌患者分为动脉灌注化疗联合放疗（IAC）组和静脉诱导化疗联合放疗（IVC）组。治疗后4周， IAC 组与 IVC 组的完全缓解（CR）率分别为94．0％、70．0％，差异有统计学意义（P ＜0．05）；治疗后12周，IAC 组与 IVC组的 CR 率分别为98．0％、72．0％，差异有统计学意义（P ＜0．05）。两组治疗有效率均为100％，均未发现远处转移病例。两组之间3、4级急性毒副反应发生率比较，差异无统计学意义（P ＞0．05）。因此动脉灌注诱导化疗联合后期同步放化疗疗效可靠、安全。
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| 关 键 词： | 动脉灌注 放化疗 局部晚期鼻咽癌 近期疗效 |
Early clinical effect of intra-arterial induction chemotherapy on Locally advanced nasopharyngeal carcinoma |
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| Abstract: | LANC was randomly divided into IAC,intra-arterial neoadjuvant chemotherapy followed by concurrent chemo-radiotherapy and IVC,intravenous neoadjuvant chemotherapy combined with radiotherapy.After 4 weeks, the complete remission rate (CR)in group IAC and IVC was 94.0% vs 70.0%,with statistical significance (P <0.05),and at 12 weeks,98.0% vs 72.0%,with statistical significance (P <0.05).The effective rate of the two groups was both 100%,and there was no distant metastasis.3,4 grade of acute toxicity incidence in Group IAC and Group IVC was 32.0% and 34.0%,respectively,without statistical significance (P >0.05).Intra-arterial induction chemotherapy followed by concurrent chemo-radiotherapy has obvious effect on LANC and perform safely. |
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| Keywords: | intra-arterial chemotherapy radio-chemotherapy locally advanced nasopharyngeal carcinoma early clinical effect |
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