定坤丹对子宫内膜异位症模型大鼠的作用 |
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引用本文: | 何闰华,王文艳,卫兵.定坤丹对子宫内膜异位症模型大鼠的作用[J].安徽医科大学学报,2015(11):1693-1695. |
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作者姓名: | 何闰华 王文艳 卫兵 |
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作者单位: | 安徽医科大学第二附属医院妇产科,合肥,230601;安徽医科大学第二附属医院妇产科,合肥,230601;安徽医科大学第二附属医院妇产科,合肥,230601 |
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基金项目: | 国家自然科学基金青年科学基金(编号81100412) |
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摘 要: | 自体子宫内膜移植法建立子宫内膜异位症(EMS)模型大鼠,比较给药前后移植物体积、大鼠血清中肿瘤坏死因子-α(TNF-α)水平、异位内膜中血管内皮生长因子(VEGF)的表达。经定坤丹治疗后移植物体积、血清 TNF-α水平、异位内膜中 VEGF 的表达与疾病模型组相比均明显下降,差异有统计学意义(P <0.05)。定坤丹对 EMS 模型大鼠的异位内膜生长有一定的抑制作用,其作用机制可能与血清 TNF-α水平降低和 VEGF 的表达减少有关。
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关 键 词: | 定坤丹 子宫内膜异位症 肿瘤坏死因子-α 血管内皮生长因子 |
Effects of DingKunDan on the endometriosis model rats |
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Abstract: | We built rats model of endometriosis applying autologus endometrial transplants to compare the graft vol-ume of the modeling rats before and after dosing,serum tumor necrosis factor alpha(TNF-α)levels in rats,and the expressions of vascular endothelial cell growth factor(VEGF)in ectopic endometrium.To compare with the control group,the graft volume of DingKunDan group was reduced and the serum TNF-αlevel declined ,and also the ex-pression of VEGF in ectopic endometrium was reduced.Their differences were statistically significant (P <0.05). DingKunDan can inhibit the growth of ectopic endometrium in endometrosis model rats.The mechanism may be re-lated to the decrease of the serum TNF-αlevel and the VEGF expression. |
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Keywords: | DingKunDan endometriosis tumor necrosis factor alpha vascular endothelial cell growth factor |
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