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| 抗CEA单克隆抗体在卵巢癌病人体内的血药动力学研究 | |
| 引用本文： | 李贵平,康福,胡立宽,张一帆,贾士铨. 抗CEA单克隆抗体在卵巢癌病人体内的血药动力学研究[J]. 山东大学学报(医学版), 1993, 0(2) |
| 作者姓名： | 李贵平 康福 胡立宽 张一帆 贾士铨 |
| 作者单位： | 核医学教研室，核医学教研室，核医学教研室，核医学教研室，核医学教研室 蚌埠医学院附属医院 |
| 摘 要： | 研究了~(131)I-CEA C50在22例卵巢癌病人放射免疫显像中的血药动力学特性。~(130)I-C50的血半清除时间平均为T1/2α=24.8h,T1/2β=40.5h(n=12)。在静脉给药后28h内约有给予放射性总剂量的50%由尿排出。循环血液中标记抗体主要在血浆中。卵巢癌病人在接受静注标记抗体后2～3周即可产生人抗鼠抗体,在体内维持至少9个月以上。二次显像应用时,抗鼠抗体的产生影响了二次显像效果,限制了鼠源性单抗的反复应用。 |
| 关 键 词： | 卵巢肿瘤 癌胚抗原 抗体 单克隆 动力学 放射性核素成象 |
BIOKINETICS OF MONOCLONAL ANTIBODIES AGAINST CEA IN OVARIAN CANCER PATIENTS |
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| Li Guiping,et al Dept.of Nuclear Medicine,Shandong Medical University. BIOKINETICS OF MONOCLONAL ANTIBODIES AGAINST CEA IN OVARIAN CANCER PATIENTS[J]. Journal of Shandong University:Health Sciences, 1993, 0(2) | |
| Authors: | Li Guiping et al Dept.of Nuclear Medicine Shandong Medical University |
| Abstract: | The biokinetics of ~(131)i-labelled monoclonal antibodies againstCEA have been examined in 22 ovarian cancer patients who were receivinglabelled antibody in diagnostic immunoscintigraphy trials.A hi-phasic declineof radiolabelled preparations was measured with initial half-lives 24.8 hoursand then with 40.5 hours in second half-lives.Blood-borne radioactivity wasassociated predominantly with plasma rather than cellular elements.Urinaryexcretion of radioactivity was about 50% of injected dose in the first 28 hours.However,anti-mouse-IgG antibody(HAMA)detected 14 days after admini-stration of radiolabelled antibody and was present for at least 9 months,and has implications for the efficiency of repeated image studies. |
| Keywords: | Ovarian neoplasms Carcinoembryonic antigen Antibodies monoclonal Kinetics Radionuclide imaging |
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