Increased GABAergic transmission aggravates nucleus basalis magnocellularis lesion-induced behavioral deficits |
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| Authors: | Paavo Riekkinen Jr., Jouni Sirvi , Pekka J k l , Maria Mazurkiewicz, Antti Valjakka, Minna Riekkinen,Paavo Riekkinen |
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| Affiliation: | Department of Neurology, University of Kuopio, Finland. |
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| Abstract: | ![]()
Quisqualic acid NBM lesions had no effect on water maze performance, but slightly impaired passive avoidance acquisition. GammavinylGABA treatment alone had no effect on the passive avoidance and water maze performance, but aggravated acquisition deficit in rats subjected to NBM lesioning. However, gammavinylGABA-treated NBM-lesioned rats reached control level of performance. |
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| Keywords: | NBM GVG Water-maze Passive avoidance Acquisition |
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