恒速持续与间歇静脉滴注脱氧氟脲苷毒副作用比较

目的比较胃肠癌术后恒速持续静脉滴注与间歇静脉滴注脱氧氟脲苷对病人的毒副作用。方法选择2002年1月至2005年12月间的80例胃肠癌手术后病人，随机分为两组，每组40例，治疗组在静滴顺铂和表阿霉素的基础上恒速持续静脉滴注FUDR 500mg／24h，持续72h；对照组在上述化疗基础上间歇静脉滴注FUDR 500mg／d，2-3h／次，1～5d。化疗期间及结束后，查血常规、肝肾功能，观察毒副反应。结果治疗组仅29例完成化疗，均在化疗后d3出现逐渐加重的口腔炎，重者无法进食，饮水；对照组40例全部完成化疗，仅2例发生以口腔炎为主的毒副反应，且程度轻，不影响进食，饮水；两组病人肝肾功能及造血功能无明显改变。结论长时间（72h）恒速持续静脉滴注FUDR可导致较为严重的、以口腔炎为主的化疗毒副反应。

Comparison of floxuridine side effect with constant speed continuous intervenous drop infusion and interval intervenous drop infusion

Objective To compare with constant speed continuous intervenous drop infusion and interval intervenous drop infusion for floxuridine side effect. Methods 80 gastrointestinal cancer patients after operation from Jan 2002 to Dec 2005 were randomly divided into two groups. Treatment group was used by constant speed continuous intervenous drop infusion for FUDR 500mg/24h, 72h combined with cisplatin and pharmorubicin. Control group was used by interval intervenous drop infusion for floxuridine 500mg/d, 2-3h every time, 1-5 days. During and after chems, blood routine, liver and kidney function were detected and side effect was observed. Results 29 patients were completed the treatment in treatment group, after 3 days all patients presented progressive stomatitis, severe patients could not take food and drink water. All patients were completed the treatment in the control group, only 2 patients presented stomatitis, the severity was light and had no effect on taking food and drinking water. There were no changes in blood routine, liver and kidney function between two groups. Conclusions Constant speed continuous intervenous drop infusion for floxuridine might cause the side effect of severe stomatitis.