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| 肺纤方对博莱霉素大鼠肺纤维化模型基质金属蛋白酶1、2及组织金属蛋白酶抑制剂1、2的影响 | |
| 引用本文： | 张晓梅,姜良铎,张伟,吴建军,鲁香凤. 肺纤方对博莱霉素大鼠肺纤维化模型基质金属蛋白酶1、2及组织金属蛋白酶抑制剂1、2的影响[J]. 中华中医药杂志, 2008, 23(3): 212-215 |
| 作者姓名： | 张晓梅 姜良铎 张伟 吴建军 鲁香凤 |
| 作者单位： | 1. 北京中医药大学东方医院,北京,100078 2. 北京中医药大学东直门医院,北京,100700 3. 北京王府医院,北京,102209 |
| 摘 要： | 目的:观察肺纤方抗大鼠肺纤维化肺基质重建的作用。方法:气管内注入博莱霉素制造大鼠肺纤维化模型,观察造模后14、28、45d模型组、假手术组、肺纤方组、泼尼松组血清基质金属蛋白酶1、2及其抑制物组织金属蛋白酶抑制剂1、2的变化。结果:肺纤方可以显著降低血清基质金属蛋白酶1、2及组织金属蛋白酶抑制剂1、2。结论:肺纤方具有抗大鼠肺纤维化基质重建作用。 |
| 关 键 词： | 肺间质纤维化 肺纤方 基质金属蛋白酶1 基质金属蛋白酶2 组织金属蛋白酶抑制剂1 组织金 |
| 收稿时间： | 2007-07-27 |
| 修稿时间： | 2007-07-27 |
Effect of FeixianFang on MMP-1,MMP-2 and TIMP-1,TIMP-2 in rats model of pulmonary fibrosis induced by bleocin |
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| ZHANG Xiao-mei,JIANG Liang-duo,ZHANG wei,WU Jian-jun,LU Xiang-feng. Effect of FeixianFang on MMP-1,MMP-2 and TIMP-1,TIMP-2 in rats model of pulmonary fibrosis induced by bleocin[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2008, 23(3): 212-215 | |
| Authors: | ZHANG Xiao-mei JIANG Liang-duo ZHANG wei WU Jian-jun LU Xiang-feng |
| Abstract: | Objective: To observe the effect of FeixianFang on matrix rebuilding of pulmonary fibrosis in rats.Methods: Rats were randomly divided into the model group,the sham operation group,the FeixianFang group and the prednisone group.Pulmonary fibrosis model was set up by intratracheal injection of bleocin.On the 14th,28th and 45th day,MMP-1,MMP-2 and TIMP-1,TIMP-2 in the serum were detected.Results: FeixianFang can significantly reduce the level of MMP-1,MMP-2 and TIMP-1,TIMP-2 in the serum of rats with pulmonary fibrosis.Conculusion: FeixianFang can inhibit matrix rebuilding in pulmonary fibrosis rats. |
| Keywords: | Pulmonary fibrosis FeixianFang MMP-1 MMP-2 TIMP-1 TIMP-2 TCM therapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |